Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

M J Finnen; A Hennessy; S McLean; Y Bisset; R Mitchell; I L Megson; R Weller

doi:10.1111/j.1365-2133.2007.08063.x

Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

M J Finnen
, A Hennessy
, S McLean
, Y Bisset
, R Mitchell
, I L Megson
, R Weller

科研成果: Article › 同行评审

21 引用（Scopus）

摘要

Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).

源语言	English
页（从-至）	494-500
页数	7
期刊	The British Journal of Dermatology
卷	157
期	3
DOI	https://doi.org/10.1111/j.1365-2133.2007.08063.x
出版状态	Published - 2007

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10.1111/j.1365-2133.2007.08063.x

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abstract = "Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).",

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AU - Finnen, M J

AU - Hennessy, A

AU - McLean, S

AU - Bisset, Y

AU - Mitchell, R

AU - Megson, I L

AU - Weller, R

PY - 2007

Y1 - 2007

N2 - Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).

AB - Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).

U2 - 10.1111/j.1365-2133.2007.08063.x

DO - 10.1111/j.1365-2133.2007.08063.x

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ER -

Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

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