Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population

Jun Wei

doi:10.1016/j.psychres.2016.03.057

Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population

Jun Wei

科研成果: Article › 同行评审

4 引用（Scopus）

摘要

A genome-wide association study of Han Chinese samples identified three
single-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to be
associated with schizophrenia. However, the replication of the TSPAN18
association was inconsistent across studies. To explore the possible reason for
poor replication, we conducted a case-control study to validate the TSPAN18
finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thought
disorder. Our result suggested that the TSPAN18 gene may be involved in the
development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia.

源语言	English
页（从-至）	263-266
页数	4
期刊	Psychiatry Research
卷	241
DOI	https://doi.org/10.1016/j.psychres.2016.03.057
出版状态	Published - 11 5月 2016

访问文件

10.1016/j.psychres.2016.03.057许可: CC BY-NC

引用此

@article{eded1e081d604882af6723a338f30b34,

title = "Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population",

abstract = "A genome-wide association study of Han Chinese samples identified three single-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to be associated with schizophrenia. However, the replication of the TSPAN18 association was inconsistent across studies. To explore the possible reason for poor replication, we conducted a case-control study to validate the TSPAN18 finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thought disorder. Our result suggested that the TSPAN18 gene may be involved in the development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia. ",

keywords = "Tetraspanin 18, Schizophrenia, Heterogeneity",

author = "Jun Wei",

year = "2016",

month = may,

day = "11",

doi = "10.1016/j.psychres.2016.03.057",

language = "English",

volume = "241",

pages = "263--266",

journal = "Psychiatry Research ",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population

AU - Wei, Jun

PY - 2016/5/11

Y1 - 2016/5/11

N2 - A genome-wide association study of Han Chinese samples identified three single-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to be associated with schizophrenia. However, the replication of the TSPAN18 association was inconsistent across studies. To explore the possible reason for poor replication, we conducted a case-control study to validate the TSPAN18 finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thought disorder. Our result suggested that the TSPAN18 gene may be involved in the development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia.

AB - A genome-wide association study of Han Chinese samples identified three single-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to be associated with schizophrenia. However, the replication of the TSPAN18 association was inconsistent across studies. To explore the possible reason for poor replication, we conducted a case-control study to validate the TSPAN18 finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thought disorder. Our result suggested that the TSPAN18 gene may be involved in the development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia.

KW - Tetraspanin 18

KW - Schizophrenia

KW - Heterogeneity

U2 - 10.1016/j.psychres.2016.03.057

DO - 10.1016/j.psychres.2016.03.057

M3 - Article

SN - 0165-1781

VL - 241

SP - 263

EP - 266

JO - Psychiatry Research

JF - Psychiatry Research

ER -

Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population

摘要

访问文件

指纹

引用此