Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Wan-Seob Cho; Rodger Duffin; Sarah E M Howie; Chris J Scotton; William A H Wallace; William Macnee; Mark Bradley; Ian L Megson; Ken Donaldson

doi:10.1186/1743-8977-8-27

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Wan-Seob Cho
, Rodger Duffin
, Sarah E M Howie
, Chris J Scotton
, William A H Wallace
, William Macnee
, Mark Bradley
, Ian L Megson
, Ken Donaldson

科研成果: Article › 同行评审

397 引用（Scopus）

摘要

Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the pathological changes induced by ZnONP and their possible mechanism of action.

源语言	English
页（从-至）	27
期刊	Particle and Fibre Toxicology
卷	8
DOI	https://doi.org/10.1186/1743-8977-8-27
出版状态	Published - 2011

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10.1186/1743-8977-8-27

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AU - Macnee, William

AU - Bradley, Mark

AU - Megson, Ian L

AU - Donaldson, Ken

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Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

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