Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Wan-Seob Cho; Rodger Duffin; Mark Bradley; Ian L Megson; William Macnee; Jong Kwon Lee; Jayoung Jeong; Ken Donaldson

doi:10.1186/1743-8977-10-55

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Wan-Seob Cho
, Rodger Duffin
, Mark Bradley
, Ian L Megson
, William Macnee
, Jong Kwon Lee
, Jayoung Jeong
, Ken Donaldson

科研成果: Article › 同行评审

116 引用（Scopus）

摘要

Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs makes in vivo toxicity tests undesirable on both ethical and financial grounds, creating an urgent need for development of in vitro cell-based assays that accurately predict in vivo toxicity and facilitate safe nanotechnology.

源语言	English
页（从-至）	55
期刊	Particle and Fibre Toxicology
卷	10
期	1
DOI	https://doi.org/10.1186/1743-8977-10-55
出版状态	Published - 25 10月 2013

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10.1186/1743-8977-10-55

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AU - Macnee, William

AU - Lee, Jong Kwon

AU - Jeong, Jayoung

AU - Donaldson, Ken

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AB - Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs makes in vivo toxicity tests undesirable on both ethical and financial grounds, creating an urgent need for development of in vitro cell-based assays that accurately predict in vivo toxicity and facilitate safe nanotechnology.

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Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

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