Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Xuguang Zhang; Susan C McGeoch; Alexandra M Johnstone; Grietje Holtrop; Alan A Sneddon; Sandra M Macrury; Ian L Megson; Donald W M Pearson; Prakash Abraham; Baukje De Roos; Gerald E Lobley; Niamh O'Kennedy

doi:10.1007/s11239-013-1000-2

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Xuguang Zhang
, Susan C McGeoch
, Alexandra M Johnstone
, Grietje Holtrop
, Alan A Sneddon
, Sandra M Macrury
, Ian L Megson
, Donald W M Pearson
, Prakash Abraham
, Baukje De Roos
, Gerald E Lobley
, Niamh O'Kennedy

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68 引用（Scopus）

摘要

This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P

源语言	English
期刊	Journal of Thrombosis and Thrombolysis
DOI	https://doi.org/10.1007/s11239-013-1000-2
出版状态	Published - 5 10月 2013

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10.1007/s11239-013-1000-2

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Zhang, X., McGeoch, S. C., Johnstone, A. M., Holtrop, G., Sneddon, A. A., Macrury, S. M., Megson, I. L., Pearson, D. W. M., Abraham, P., De Roos, B., Lobley, G. E., & O'Kennedy, N. (2013). Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status. Journal of Thrombosis and Thrombolysis. https://doi.org/10.1007/s11239-013-1000-2

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title = "Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status",

abstract = "This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P ",

author = "Xuguang Zhang and McGeoch, \{Susan C\} and Johnstone, \{Alexandra M\} and Grietje Holtrop and Sneddon, \{Alan A\} and Macrury, \{Sandra M\} and Megson, \{Ian L\} and Pearson, \{Donald W M\} and Prakash Abraham and \{De Roos\}, Baukje and Lobley, \{Gerald E\} and Niamh O'Kennedy",

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Zhang, X, McGeoch, SC, Johnstone, AM, Holtrop, G, Sneddon, AA, Macrury, SM, Megson, IL, Pearson, DWM, Abraham, P, De Roos, B, Lobley, GE & O'Kennedy, N 2013, 'Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status', Journal of Thrombosis and Thrombolysis. https://doi.org/10.1007/s11239-013-1000-2

TY - JOUR

T1 - Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

AU - Zhang, Xuguang

AU - McGeoch, Susan C

AU - Johnstone, Alexandra M

AU - Holtrop, Grietje

AU - Sneddon, Alan A

AU - Macrury, Sandra M

AU - Megson, Ian L

AU - Pearson, Donald W M

AU - Abraham, Prakash

AU - De Roos, Baukje

AU - Lobley, Gerald E

AU - O'Kennedy, Niamh

PY - 2013/10/5

Y1 - 2013/10/5

N2 - This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P

AB - This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P

U2 - 10.1007/s11239-013-1000-2

DO - 10.1007/s11239-013-1000-2

M3 - Article

C2 - 24097206

SN - 1573-742X

JO - Journal of Thrombosis and Thrombolysis

JF - Journal of Thrombosis and Thrombolysis

ER -

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

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