New advances in blockade of the renin angiotensin system- The role of renin blockade

Sandra MacRury; L F Clark; G F Rushworth; Stephen J Leslie

doi:10.2174/157340210793611677

New advances in blockade of the renin angiotensin system- The role of renin blockade

Sandra MacRury
, L F Clark
, G F Rushworth
, Stephen J Leslie

科研成果 › 同行评审

摘要

Direct Renin Inhibitors (DRIs) are a new class of medication, and are the first which block the rate-limiting step of the renin-angiotensin-aldosterone-system (RAAS). Aliskiren, the first licensed orally active DRI, has been shown to be an effective antihypertensive agent. This review article outlines the pharmacological basis for DRI therapy, from discovery of the class to ongoing clinical trials and novel therapeutic applications of aliskiren.

源语言	English
页（从-至）	222
页数	231
期刊	Current Hypertension Reviews
卷	6
期	4
DOI	https://doi.org/10.2174/157340210793611677
出版状态	Published - 2014

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10.2174/157340210793611677

http://benthamscience.com/journal/abstracts.php?journalID=chr&articleID=72883

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New advances in blockade of the renin angiotensin system- The role of renin blockade

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