@article{c0465841cf62405ea460329b8616725a,
title = "Functional analysis of the ATM-p53-p21 pathway in the LRF CLL4 trial blockade at the level of p21 is associated with short response duration",
abstract = "This study sought to establish whether functional analysis of the ATM-p53-p21 pathway adds to the information provided by currently available prognostic factors in patients with chronic lymphocytic leukemia (CLL) requiring frontline chemotherapy.",
keywords = "Aged, Antineoplastic Combined Chemotherapy Protocols, Ataxia Telangiectasia Mutated Proteins, Cell Cycle Proteins, Chlorambucil, Cyclin-Dependent Kinase Inhibitor p21, Cyclophosphamide, DNA-Binding Proteins, Female, Flow Cytometry, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Leukocytes, Mononuclear, Male, Middle Aged, Mutation, Prognosis, Protein-Serine-Threonine Kinases, Randomized Controlled Trials as Topic, Signal Transduction, Survival Analysis, Tumor Suppressor Protein p53, Tumor Suppressor Proteins, Vidarabine",
author = "Ke Lin and Janet Adamson and Johnson, \{Gillian G\} and Anthony Carter and Melanie Oates and Rachel Wade and Sue Richards and David Gonzalez and Estella Matutes and Claire Dearden and Oscier, \{David G\} and Daniel Catovsky and Pettitt, \{Andrew R\}",
year = "2012",
month = aug,
day = "1",
doi = "10.1158/1078-0432.CCR-11-2936",
language = "English",
volume = "18",
pages = "4191--200",
journal = "Clinical Cancer Research : An Official Journal of the American Association for Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "15",
}
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