Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry

Tina Rozaklis; Steven L Ramsay; Enzo Ranieri; John J Hopwood; Peter J Meikle; Phil Whitfield

Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry

Tina Rozaklis
, Steven L Ramsay
, Enzo Ranieri
, John J Hopwood
, Peter J Meikle
, Phil Whitfield

科研成果: Article › 同行评审

64 引用（Scopus）

摘要

The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the efficacy of therapy and methods to quantify these markers in biologic samples. In Pompe disease, the concentration of a tetrasaccharide, consisting of four glucose residues, is reputedly increased in urine and plasma, but faster and more sensitive methods are required for the analysis of this, and other oligosaccharides, from biologic fluids.

源语言	English
页（从-至）	131-9
页数	9
期刊	Clinical Chemistry
卷	48
期	1
出版状态	Published - 1月 2002

引用此

@article{2c9fc74699264917ac288158b972034d,

title = "Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry",

abstract = "The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the efficacy of therapy and methods to quantify these markers in biologic samples. In Pompe disease, the concentration of a tetrasaccharide, consisting of four glucose residues, is reputedly increased in urine and plasma, but faster and more sensitive methods are required for the analysis of this, and other oligosaccharides, from biologic fluids.",

keywords = "Adolescent, Adult, Antipyrine, Child, Child, Preschool, Glycogen Storage Disease Type II, Humans, Indicators and Reagents, Infant, Infant, Newborn, Middle Aged, Oligosaccharides, Sensitivity and Specificity, Spectrometry, Mass, Electrospray Ionization",

author = "Tina Rozaklis and Ramsay, \{Steven L\} and Enzo Ranieri and Hopwood, \{John J\} and Meikle, \{Peter J\} and Phil Whitfield",

year = "2002",

month = jan,

language = "English",

volume = "48",

pages = "131--9",

journal = "Clinical Chemistry",

issn = "0009-9147",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry

AU - Rozaklis, Tina

AU - Ramsay, Steven L

AU - Ranieri, Enzo

AU - Hopwood, John J

AU - Meikle, Peter J

AU - Whitfield, Phil

PY - 2002/1

Y1 - 2002/1

N2 - The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the efficacy of therapy and methods to quantify these markers in biologic samples. In Pompe disease, the concentration of a tetrasaccharide, consisting of four glucose residues, is reputedly increased in urine and plasma, but faster and more sensitive methods are required for the analysis of this, and other oligosaccharides, from biologic fluids.

AB - The development of therapies for lysosomal storage disorders has created a need for biochemical markers to monitor the efficacy of therapy and methods to quantify these markers in biologic samples. In Pompe disease, the concentration of a tetrasaccharide, consisting of four glucose residues, is reputedly increased in urine and plasma, but faster and more sensitive methods are required for the analysis of this, and other oligosaccharides, from biologic fluids.

KW - Adolescent

KW - Adult

KW - Antipyrine

KW - Child

KW - Child, Preschool

KW - Glycogen Storage Disease Type II

KW - Humans

KW - Indicators and Reagents

KW - Infant

KW - Infant, Newborn

KW - Middle Aged

KW - Oligosaccharides

KW - Sensitivity and Specificity

KW - Spectrometry, Mass, Electrospray Ionization

M3 - Article

C2 - 11751548

SN - 0009-9147

VL - 48

SP - 131

EP - 139

JO - Clinical Chemistry

JF - Clinical Chemistry

IS - 1

ER -

Determination of oligosaccharides in Pompe disease by electrospray ionization tandem mass spectrometry

摘要

指纹

引用此