TY - JOUR
T1 - Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population
AU - Sun, Shilong
AU - Wang, Fan
AU - Wei, Jun
AU - Cao, Lian Yuan
AU - Wu, Gui Ying
AU - Lu, Lin
AU - Kosten, Therese A
AU - Kosten, Thomas R
AU - Zhang, Xiang Yang
PY - 2008/7/25
Y1 - 2008/7/25
N2 - Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor subunits for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IL3RA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex- matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi2=6.24, d.f.=1, p=0.013, odds ratio (OR)=1.35, 95% CI 1.07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.
AB - Schizophrenia has been observed to be associated with various abnormalities in cytokines and cytokine receptors. Three very recent reports showed the evidence that the IL3 gene, colony stimulating factor 2 receptor alpha (CSF2RA), beta (CSF2RB) and IL-3 receptor alpha (IL3RA), the IL-specific receptor subunits for CSF2 and IL3, respectively, are associated with schizophrenia. To examine the association of the IL3RA polymorphism (rs6603272) with schizophrenia in a Chinese population, 310 physically healthy patients with schizophrenia were compared with 330 age-, sex- matched normal controls. Statistically significant differences were observed in both allelic and genotypic frequencies of the rs6603272 polymorphism (Allele, chi2=6.24, d.f.=1, p=0.013, odds ratio (OR)=1.35, 95% CI 1.07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia.
KW - Alleles
KW - Asian Continental Ancestry Group
KW - Female
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - Humans
KW - Interleukin-3 Receptor alpha Subunit
KW - Male
KW - Polymorphism, Genetic
KW - Receptors, Interleukin-3
KW - Schizophrenia
U2 - 10.1016/j.neulet.2008.05.029
DO - 10.1016/j.neulet.2008.05.029
M3 - Article
C2 - 18547720
SN - 0304-3940
VL - 440
SP - 35
EP - 37
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -