Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

A G Japp; N L Cruden; G Barnes; N van Gemeren; J Mathews; J Adamson; N R Johnston; M A Denvir; I L Megson; A D Flapan; D E Newby

doi:10.1161/CIRCULATIONAHA.109.911339

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

A G Japp
, N L Cruden
, G Barnes
, N van Gemeren
, J Mathews
, J Adamson
, N R Johnston
, M A Denvir
, I L Megson
, A D Flapan
, D E Newby

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317 引用（Scopus）

摘要

Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.

源语言	English
页（从-至）	1818-27
页数	10
期刊	Circulation
卷	121
期	16
DOI	https://doi.org/10.1161/CIRCULATIONAHA.109.911339
出版状态	Published - 2010

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10.1161/CIRCULATIONAHA.109.911339

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title = "Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure",

abstract = "Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.",

author = "Japp, \{A G\} and Cruden, \{N L\} and G Barnes and \{van Gemeren\}, N and J Mathews and J Adamson and Johnston, \{N R\} and Denvir, \{M A\} and Megson, \{I L\} and Flapan, \{A D\} and Newby, \{D E\}",

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AU - Japp, A G

AU - Cruden, N L

AU - Barnes, G

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AU - Mathews, J

AU - Adamson, J

AU - Johnston, N R

AU - Denvir, M A

AU - Megson, I L

AU - Flapan, A D

AU - Newby, D E

PY - 2010

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JO - Circulation

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Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

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