A study of the relationship between the DBH activity in serum and a MspI polymorphic site in intron 9 of the human DBH gene in schizophrenia

J Wei; C N Ramchand; G P Hemmings

A study of the relationship between the DBH activity in serum and a MspI polymorphic site in intron 9 of the human DBH gene in schizophrenia

J Wei
, C N Ramchand
, G P Hemmings

科研成果: Article › 同行评审

8 引用（Scopus）

摘要

Intron 9 of the human dopamine beta-hydroxylase (DBH) gene was amplified using a long PCR procedure in unrelated patients with schizophrenia and unrelated control subjects. MspI digestion of the PCR fragments showed a two allele polymorphism. A1 and A2 Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among the three groups carrying the A1/A2 genotype, the drug-free and drug treated patients, and the control subjects (H = 12.2, df = 2, p

源语言	English
页（从-至）	77-80
页数	4
期刊	Schizophrenia Research
卷	22
期	1
出版状态	Published - 18 10月 1996

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abstract = "Intron 9 of the human dopamine beta-hydroxylase (DBH) gene was amplified using a long PCR procedure in unrelated patients with schizophrenia and unrelated control subjects. MspI digestion of the PCR fragments showed a two allele polymorphism. A1 and A2 Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among the three groups carrying the A1/A2 genotype, the drug-free and drug treated patients, and the control subjects (H = 12.2, df = 2, p ",

keywords = "Adult, Antipsychotic Agents, Base Sequence, Deoxyribonuclease HpaII, Dopamine beta-Hydroxylase, Female, Genotype, Humans, Introns, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Schizophrenia",

author = "J Wei and Ramchand, \{C N\} and Hemmings, \{G P\}",

year = "1996",

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T1 - A study of the relationship between the DBH activity in serum and a MspI polymorphic site in intron 9 of the human DBH gene in schizophrenia

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AU - Ramchand, C N

AU - Hemmings, G P

PY - 1996/10/18

Y1 - 1996/10/18

N2 - Intron 9 of the human dopamine beta-hydroxylase (DBH) gene was amplified using a long PCR procedure in unrelated patients with schizophrenia and unrelated control subjects. MspI digestion of the PCR fragments showed a two allele polymorphism. A1 and A2 Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among the three groups carrying the A1/A2 genotype, the drug-free and drug treated patients, and the control subjects (H = 12.2, df = 2, p

AB - Intron 9 of the human dopamine beta-hydroxylase (DBH) gene was amplified using a long PCR procedure in unrelated patients with schizophrenia and unrelated control subjects. MspI digestion of the PCR fragments showed a two allele polymorphism. A1 and A2 Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among the three groups carrying the A1/A2 genotype, the drug-free and drug treated patients, and the control subjects (H = 12.2, df = 2, p

KW - Adult

KW - Antipsychotic Agents

KW - Base Sequence

KW - Deoxyribonuclease HpaII

KW - Dopamine beta-Hydroxylase

KW - Female

KW - Genotype

KW - Humans

KW - Introns

KW - Male

KW - Middle Aged

KW - Polymerase Chain Reaction

KW - Polymorphism, Restriction Fragment Length

KW - Schizophrenia

M3 - Article

C2 - 8908693

SN - 0920-9964

VL - 22

SP - 77

EP - 80

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1

ER -

A study of the relationship between the DBH activity in serum and a MspI polymorphic site in intron 9 of the human DBH gene in schizophrenia

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