A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

J Wei; G P Hemmings

doi:10.1016/j.plefa.2003.12.018

A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

J Wei
, G P Hemmings

科研成果: Article › 同行评审

42 引用（Scopus）

摘要

Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

源语言	English
页（从-至）	413-5
页数	3
期刊	Prostaglandins Leukotrienes and Essential Fatty Acids
卷	70
期	4
DOI	https://doi.org/10.1016/j.plefa.2003.12.018
出版状态	Published - 4月 2004

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10.1016/j.plefa.2003.12.018

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abstract = "Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.",

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AU - Hemmings, G P

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AB - Six single nucleotide polymorphisms (SNPs) present in the PTGS2/PLA2G4A locus were detected among 118 British family trios of schizophrenia patients. The transmission disequilibrium test showed that SNP4 located in the 5'-flanking region of the PLA2G4A gene was associated with schizophrenia and that the haplotype analysis also showed a genetic association between the PTGS2 gene and schizophrenia. Because these two genes are arranged in a head-to-head configuration and separated by just about 149kb of DNA, they may have a combined effect on susceptibility to schizophrenia in some cases.

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KW - Alleles

KW - Cyclooxygenase 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Predisposition to Disease

KW - Great Britain

KW - Haplotypes

KW - Humans

KW - Male

KW - Membrane Proteins

KW - Phospholipases A

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Prostaglandin-Endoperoxide Synthases

KW - Schizophrenia

U2 - 10.1016/j.plefa.2003.12.018

DO - 10.1016/j.plefa.2003.12.018

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C2 - 15041036

SN - 0952-3278

VL - 70

SP - 413

EP - 415

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 4

ER -

A study of a genetic association between the PTGS2/PLA2G4A locus and schizophrenia

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