A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J Webb; Ian L Megson; Nigel P Botting

doi:10.1039/c2cc38382a

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang
, Agnieszka Kulczynska
, David J Webb
, Ian L Megson
, Nigel P Botting

科研成果: Article › 同行评审

11 引用（Scopus）

摘要

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

源语言	English
页（从-至）	1389-1391
页数	3
期刊	Chemical Communications
卷	49
期	14
DOI	https://doi.org/10.1039/c2cc38382a
出版状态	Published - 18 2月 2013

访问文件

10.1039/c2cc38382a

http://www.scopus.com/inward/record.url?eid=2-s2.0-84872738180&partnerID=40&md5=49868bb517891ebacc063da22a3a36e4

引用此

@article{439f50ae1b164ce2a9ae6dc1ceaf39c2,

title = "A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation",

abstract = "This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).",

keywords = "Acute Kidney Injury, Guanidines, Humans, Nitric Oxide, Prodrugs, Vasodilator Agents, gamma-Glutamyltransferase",

author = "Qingzhi Zhang and Agnieszka Kulczynska and Webb, \{David J\} and Megson, \{Ian L\} and Botting, \{Nigel P\}",

note = "cited By (since 1996)0",

year = "2013",

month = feb,

day = "18",

doi = "10.1039/c2cc38382a",

language = "English",

volume = "49",

pages = "1389--1391",

journal = "Chemical Communications",

issn = "1364-548X",

publisher = "Royal Society of Chemistry",

number = "14",

}

TY - JOUR

T1 - A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

AU - Zhang, Qingzhi

AU - Kulczynska, Agnieszka

AU - Webb, David J

AU - Megson, Ian L

AU - Botting, Nigel P

N1 - cited By (since 1996)0

PY - 2013/2/18

Y1 - 2013/2/18

N2 - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

AB - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

KW - Acute Kidney Injury

KW - Guanidines

KW - Humans

KW - Nitric Oxide

KW - Prodrugs

KW - Vasodilator Agents

KW - gamma-Glutamyltransferase

U2 - 10.1039/c2cc38382a

DO - 10.1039/c2cc38382a

M3 - Article

C2 - 23322269

SN - 1364-548X

VL - 49

SP - 1389

EP - 1391

JO - Chemical Communications

JF - Chemical Communications

IS - 14

ER -

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

摘要

访问文件

指纹

引用此