A new approach for creating double-stranded DNA biosensors

Sergey G. Skuridin; Yuri M. Yevdokimov; Vladimir S. Efimov; Jennifer M. Hall; Anthony P.f. Turner

doi:10.1016/0956-5663(96)89439-5

A new approach for creating double-stranded DNA biosensors

Sergey G. Skuridin
, Yuri M. Yevdokimov
, Vladimir S. Efimov
, Jennifer M. Hall
, Anthony P.f. Turner

Centre for Rural Health Sciences

科研成果: Article › 同行评审

28 引用（Scopus）

摘要

The principle of ‘sandwich’-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was ∼ 10−14M.

源语言	English
页（从-至）	903-911
期刊	Biosensors and Bioelectronics
卷	11
期	9
DOI	https://doi.org/10.1016/0956-5663(96)89439-5
出版状态	Published - 1 1月 1996

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10.1016/0956-5663(96)89439-5

http://linkinghub.elsevier.com/retrieve/pii/0956566396894395

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AU - Turner, Anthony P.f.

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AB - The principle of ‘sandwich’-type biosensors based on liquid-crystalline dispersions formed from [DNA-polycation] complexes is outlined. These biosensors will find application in the determination of a range of compounds and physical factors that affect the ability of a given polycationic molecule to maintain intermolecular crosslinks between neighbouring DNA molecules. In the case of liquid-crystalline dispersions formed from [DNA-protamine] complexes, the lowest concentration of hydrolytic enzyme (trypsin) detectable was ∼ 10−14M.

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A new approach for creating double-stranded DNA biosensors

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