Perinatal circumstances and risk of offspring suicide: Birth cohort study

Background: A higher risk of suicide has been associated with low birth weight in one study, but not yet replicated. Higher birth order has been associated with self-harm, but not with suicide. Aims: To examine the relationship between perinatal circumstances and subsequent young adult suicide in Scotland. Method: Using linked data from the Scottish Morbidity Record and Scottish death records, a birth cohort of 1061830 people was followed-up for a mean of 25.1 years. Data were analysed using Cox regression. Results: Higher maternal parity, younger maternal age (< 25 years), non-professional parental occupations and low birth weight (<2500 g) were independently associated with higher suicide risk of offspring as young adults. There was no independent association with gestational age. Conclusions: Our findings provide support for the influence of maternal circumstance and foetal experience on subsequent mental health.