Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

Y.a c Yang; D.a Du; P.a Gao; X.a b Zhang; N.b Wu; F.a Wang; Z.b Wang; L.b Ye; J.a Wu; Ian Megson; Jun Wei

doi:10.1007/s12975-010-0045-1

Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

Y.a c Yang
, D.a Du
, P.a Gao
, X.a b Zhang
, N.b Wu
, F.a Wang
, Z.b Wang
, L.b Ye
, J.a Wu
, Ian Megson
, Jun Wei

Resultado de pesquisa: Article › revisão de pares

Resumo

The present study aimed to investigate the interaction between the Ser447Term polymorphism in the lipoprotein lipase (LPL) gene and some common risk factors for stroke. A total of 704 unrelated patients with ischemic stroke were recruited for genetic analysis; they were all of Han Chinese origin. These patients were classified into subgroups based on their exposure to stroke-related risk factors, including type 2 diabetes, hypertension, smoking, and hyperlipidemia. The Ser447Term polymorphism was genotyped by PCR-based restriction fragment length polymorphism analysis. The chi-square (? 2) test showed that the frequency of Ser447Term G allele was significantly higher in stroke patients with a history of diabetes than in those without a history of diabetes (? 2 = 7.25, P = 0.007, OR = 1.78, 95%CI 1.18-2.68). Allelic association was not observed in patients exposed to the other three stroke-related risk factors. The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke. ? 2010 Springer Science+Business Media, LLC.

Idioma original	Undefined/Unknown
Páginas (de-até)	101-105
Número de páginas	5
Revista	Translational Stroke Research
Volume	2
Número de emissão	1
DOIs	https://doi.org/10.1007/s12975-010-0045-1
Estado da publicação	Published - 2011

ODS da ONU

Este resultado contribui para o(s) seguinte(s) Objetivo(s) de Desenvolvimento Sustentável

Good health and well being

Acesso ao documento

10.1007/s12975-010-0045-1

http://www.scopus.com/inward/record.url?eid=2-s2.0-79951516436&partnerID=40&md5=5a25452308ab184cac5efbe0740228fd

Citar isto

Yang, Y. A. C., Du, D. A., Gao, P. A., Zhang, X. A. B., Wu, N. B., Wang, F. A., Wang, Z. B., Ye, L. B., Wu, J. A., Megson, I., & Wei, J. (2011). Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke. Translational Stroke Research, 2(1), 101-105. https://doi.org/10.1007/s12975-010-0045-1

@article{dd9de864596742c0b6d87a275a3375ea,

title = "Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke",

abstract = "The present study aimed to investigate the interaction between the Ser447Term polymorphism in the lipoprotein lipase (LPL) gene and some common risk factors for stroke. A total of 704 unrelated patients with ischemic stroke were recruited for genetic analysis; they were all of Han Chinese origin. These patients were classified into subgroups based on their exposure to stroke-related risk factors, including type 2 diabetes, hypertension, smoking, and hyperlipidemia. The Ser447Term polymorphism was genotyped by PCR-based restriction fragment length polymorphism analysis. The chi-square (? 2) test showed that the frequency of Ser447Term G allele was significantly higher in stroke patients with a history of diabetes than in those without a history of diabetes (? 2 = 7.25, P = 0.007, OR = 1.78, 95\%CI 1.18-2.68). Allelic association was not observed in patients exposed to the other three stroke-related risk factors. The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke. ? 2010 Springer Science+Business Media, LLC.",

author = "Yang, \{Y.a c\} and D.a Du and P.a Gao and Zhang, \{X.a b\} and N.b Wu and F.a Wang and Z.b Wang and L.b Ye and J.a Wu and Ian Megson and Jun Wei",

note = "cited By (since 1996)0",

year = "2011",

doi = "10.1007/s12975-010-0045-1",

language = "Undefined/Unknown",

volume = "2",

pages = "101--105",

journal = "Translational Stroke Research",

issn = "1868-601X",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - Investigation of the Interaction Between the Ser447Term Polymorphism of Lipoprotein Lipase and the Stroke-Related Risk Factors in Ischemic Stroke

AU - Yang, Y.a c

AU - Du, D.a

AU - Gao, P.a

AU - Zhang, X.a b

AU - Wu, N.b

AU - Wang, F.a

AU - Wang, Z.b

AU - Ye, L.b

AU - Wu, J.a

AU - Megson, Ian

AU - Wei, Jun

N1 - cited By (since 1996)0

PY - 2011

Y1 - 2011

N2 - The present study aimed to investigate the interaction between the Ser447Term polymorphism in the lipoprotein lipase (LPL) gene and some common risk factors for stroke. A total of 704 unrelated patients with ischemic stroke were recruited for genetic analysis; they were all of Han Chinese origin. These patients were classified into subgroups based on their exposure to stroke-related risk factors, including type 2 diabetes, hypertension, smoking, and hyperlipidemia. The Ser447Term polymorphism was genotyped by PCR-based restriction fragment length polymorphism analysis. The chi-square (? 2) test showed that the frequency of Ser447Term G allele was significantly higher in stroke patients with a history of diabetes than in those without a history of diabetes (? 2 = 7.25, P = 0.007, OR = 1.78, 95%CI 1.18-2.68). Allelic association was not observed in patients exposed to the other three stroke-related risk factors. The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke. ? 2010 Springer Science+Business Media, LLC.

AB - The present study aimed to investigate the interaction between the Ser447Term polymorphism in the lipoprotein lipase (LPL) gene and some common risk factors for stroke. A total of 704 unrelated patients with ischemic stroke were recruited for genetic analysis; they were all of Han Chinese origin. These patients were classified into subgroups based on their exposure to stroke-related risk factors, including type 2 diabetes, hypertension, smoking, and hyperlipidemia. The Ser447Term polymorphism was genotyped by PCR-based restriction fragment length polymorphism analysis. The chi-square (? 2) test showed that the frequency of Ser447Term G allele was significantly higher in stroke patients with a history of diabetes than in those without a history of diabetes (? 2 = 7.25, P = 0.007, OR = 1.78, 95%CI 1.18-2.68). Allelic association was not observed in patients exposed to the other three stroke-related risk factors. The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke. ? 2010 Springer Science+Business Media, LLC.

U2 - 10.1007/s12975-010-0045-1

DO - 10.1007/s12975-010-0045-1

M3 - Article

SN - 1868-601X

VL - 2

SP - 101

EP - 105

JO - Translational Stroke Research

JF - Translational Stroke Research

IS - 1

ER -