No correlation between HLA-DQ 2.5, DQ 8.1 and DQ 6.2 and circulating levels of antibodies against gliadins in schizophrenia

Research output: Contribution to journalArticle

  • McLean RT, Halley L, St Clair D & Wei J

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Original languageEnglish
Article number0165-1781
Pages (from-to)325-327
Number of pages3
JournalPsychiatry Research
Volume271
Early online date1 Dec 2018
DOIs
StateE-pub ahead of print - 1 Dec 2018

    Research areas

  • Gluten antibodies; HLA; schizophrenia

Abstract

It has been suggested that gluten consumption is linked to schizophrenia, with this link strengthened through the presence of circulating anti-native gliadin antibodies (AGAs). The human leukocyte antigen (HLA) system is crucial for antigen presentation and antibody secretion but no study has examined the relationship between HLA-II variants and circulating antibodies against gliadin peptides. In this study, HLA-II variants were genotyped in patients with schizophrenia and the relationship between these variants and plasma AGA levels was examined. Although there was no association found, HLA-AGA associations could potentially serve as a marker of gluten sensitivity in patients with schizophrenia.

ID: 3413594