Lack of genetic association of the HLA-DQA1*0501 variant with schizophrenia in a Chinese population

Research output: Contribution to journalArticle

  • Songlei Guan
  • Xuan Zhang
  • Qi Xu
  • Lin Ye
  • Shunzi Jin
  • Zhenqi Wang
  • Jun Wei

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Original languageEnglish
Pages (from-to)97-98
Number of pages2
JournalPsychiatry Research
Volume208
Issue number1
DOIs
Publication statusPublished - 30 Jun 2013

Abstract

A genome-wide association (GWA) study recently revealed that the human leucocyte antigen (HLA) DQA1⁎0501 variant was strongly associated with protective effects on susceptibility to schizophrenia in a Caucasian population as its relative risk (odds ratio, OR) was 0.798 (The International Schizophrenia Consortium, 2009). Another GWA study also showed strong association of the DQA1 gene with a low risk (OR<1) of the illness (Shi et al., 2009). Schizophrenia has a lifetime prevalence of about 1% in the population worldwide. An estimated heritability of over 80% has driven the search for a causative gene involved in the common pathway of developing the illness (Sullivan et al., 2003). The present work was designed to examine the DQA1⁎0501 association with schizophrenia in a Chinese population.

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