Co-ingestion of antioxidant drinks with an unhealthy challenge meal fails to prevent post-prandial endothelial dysfunction: an open-label, crossover study in healthy older adults

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Co-ingestion of antioxidant drinks with an unhealthy challenge meal fails to prevent post-prandial endothelial dysfunction : an open-label, crossover study in healthy older adults. / Goszcz, Katarzyna; Megson, Ian; Muggeridge, David; Treweeke, Andrew; Hickson, Kirsty; Adamson, Janet.

2019. Abstract from Winter Conference 2018: Optimal diet and lifestyle strategies for the management of cardio-metabolic risk, London, United Kingdom.

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@conference{48dbdf2647b648c1ba0650657952fd07,
title = "Co-ingestion of antioxidant drinks with an unhealthy challenge meal fails to prevent post-prandial endothelial dysfunction: an open-label, crossover study in healthy older adults",
abstract = "Endothelial function is impaired for several hours after an unhealthy challenge meal (e.g high calorie, high fat)(1). This impairment hasbeen shown to be abolished in the presence of antioxidants(2), suggesting that reactive oxygen species (ROS) may play an importantrole in the induced dysfunction. In this study, we assessed whether drinks with high-antioxidant capacity impacted endothelial dys-function induced by an unhealthy challenge meal.The study was an open-label randomised crossover design: 7 healthy older adults (1 male, 6 females; BMI 25-35; mean age 57 years)were recruited to the study and completed four experimental trials. Participants received either water, orange juice, green tea or redwine with a high calorie meal (>900 kcal; >50g fat) following an overnight fast. Endothelial function (primary measure) was assessedbyflow-mediated dilatation (FMD) of the brachial artery immediately before (baseline) and two hours after the meal; blood sampleswere also taken at these time points for routine lipid and glucose analysis, as well as measurement of oxidised low density lipoprotein(ox-LDL) and oxygen radical antioxidant capacity (ORAC). Participants returned at weekly intervals to complete the remaining armsof the study. Data was analysed using a 2-factor repeated measures ANOVA.The results demonstrate that two hours following an unhealthy meal challenge there was a substantial increase in circulating tri-glycerides (≥100 \{%}, P < 0.001), but not total cholesterol or glucose (both P > 0.05). FMD was reduced by∼30 \{%} at this timepoint,but the effect was not attenuated by co-ingestion of any of the antioxidant drinks (Fig. 1). In addition, there was no effect of themeal or condition on circulating levels of ox-LDL or ORAC (P > 0.05)",
author = "Katarzyna Goszcz and Ian Megson and David Muggeridge and Andrew Treweeke and Kirsty Hickson and Janet Adamson",
note = "COPYRIGHT: \{circledC} The Authors 2019 ; Winter Conference 2018: Optimal diet and lifestyle strategies for the management of cardio-metabolic risk : The Nutrition Society ; Conference date: 04-12-2018 Through 05-01-2019",
year = "2019",
month = "3",
day = "7",
doi = "10.1017/S0029665119000314",
language = "English",
url = "https://www.nutritionsociety.org/events/winter-conference-2018-optimal-diet-and-lifestyle-strategies-management-cardio-metabolic-risk, https://www.nutritionsociety.org/events/winter-conference-2018-optimal-diet-and-lifestyle-strategies-management-cardio-metabolic-risk",

}

RIS

TY - CONF

T1 - Co-ingestion of antioxidant drinks with an unhealthy challenge meal fails to prevent post-prandial endothelial dysfunction

T2 - an open-label, crossover study in healthy older adults

AU - Goszcz,Katarzyna

AU - Megson,Ian

AU - Muggeridge,David

AU - Treweeke,Andrew

AU - Hickson,Kirsty

AU - Adamson,Janet

N1 - COPYRIGHT: © The Authors 2019

PY - 2019/3/7

Y1 - 2019/3/7

N2 - Endothelial function is impaired for several hours after an unhealthy challenge meal (e.g high calorie, high fat)(1). This impairment hasbeen shown to be abolished in the presence of antioxidants(2), suggesting that reactive oxygen species (ROS) may play an importantrole in the induced dysfunction. In this study, we assessed whether drinks with high-antioxidant capacity impacted endothelial dys-function induced by an unhealthy challenge meal.The study was an open-label randomised crossover design: 7 healthy older adults (1 male, 6 females; BMI 25-35; mean age 57 years)were recruited to the study and completed four experimental trials. Participants received either water, orange juice, green tea or redwine with a high calorie meal (>900 kcal; >50g fat) following an overnight fast. Endothelial function (primary measure) was assessedbyflow-mediated dilatation (FMD) of the brachial artery immediately before (baseline) and two hours after the meal; blood sampleswere also taken at these time points for routine lipid and glucose analysis, as well as measurement of oxidised low density lipoprotein(ox-LDL) and oxygen radical antioxidant capacity (ORAC). Participants returned at weekly intervals to complete the remaining armsof the study. Data was analysed using a 2-factor repeated measures ANOVA.The results demonstrate that two hours following an unhealthy meal challenge there was a substantial increase in circulating tri-glycerides (≥100 %, P < 0.001), but not total cholesterol or glucose (both P > 0.05). FMD was reduced by∼30 % at this timepoint,but the effect was not attenuated by co-ingestion of any of the antioxidant drinks (Fig. 1). In addition, there was no effect of themeal or condition on circulating levels of ox-LDL or ORAC (P > 0.05)

AB - Endothelial function is impaired for several hours after an unhealthy challenge meal (e.g high calorie, high fat)(1). This impairment hasbeen shown to be abolished in the presence of antioxidants(2), suggesting that reactive oxygen species (ROS) may play an importantrole in the induced dysfunction. In this study, we assessed whether drinks with high-antioxidant capacity impacted endothelial dys-function induced by an unhealthy challenge meal.The study was an open-label randomised crossover design: 7 healthy older adults (1 male, 6 females; BMI 25-35; mean age 57 years)were recruited to the study and completed four experimental trials. Participants received either water, orange juice, green tea or redwine with a high calorie meal (>900 kcal; >50g fat) following an overnight fast. Endothelial function (primary measure) was assessedbyflow-mediated dilatation (FMD) of the brachial artery immediately before (baseline) and two hours after the meal; blood sampleswere also taken at these time points for routine lipid and glucose analysis, as well as measurement of oxidised low density lipoprotein(ox-LDL) and oxygen radical antioxidant capacity (ORAC). Participants returned at weekly intervals to complete the remaining armsof the study. Data was analysed using a 2-factor repeated measures ANOVA.The results demonstrate that two hours following an unhealthy meal challenge there was a substantial increase in circulating tri-glycerides (≥100 %, P < 0.001), but not total cholesterol or glucose (both P > 0.05). FMD was reduced by∼30 % at this timepoint,but the effect was not attenuated by co-ingestion of any of the antioxidant drinks (Fig. 1). In addition, there was no effect of themeal or condition on circulating levels of ox-LDL or ORAC (P > 0.05)

U2 - 10.1017/S0029665119000314

DO - 10.1017/S0029665119000314

M3 - Abstract

ER -

ID: 3608532