The inhibition of TNF-a induced NF-kB activation by marine natural products

Florence Folmer; Marcel Jaspars; Godofredo Solano; Silvia Cristofanon; Estelle Henry; Jioji Tabudravu; Kenny Black; David Green; Frithjof Küpper; William Aalbersberg; Klaus Feussner; Mario Dicato; Marc Diederich

doi:10.1016/j.bcp.2009.05.009

The inhibition of TNF-a induced NF-kB activation by marine natural products

Florence Folmer
, Marcel Jaspars
, Godofredo Solano
, Silvia Cristofanon
, Estelle Henry
, Jioji Tabudravu
, Kenny Black
, David Green
, Frithjof Küpper
, William Aalbersberg
, Klaus Feussner
, Mario Dicato
, Marc Diederich

SAMS UHI

Résultats de recherche: Article › Revue par des pairs

40 Citations (Scopus)

Résumé

The deregulated activation of NF-kappa B is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappa B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins. Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappa B-DNA binding as well as TNF-alpha-induced I kappa B alpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappa B activation induced by an overexpression of IKK beta. Interestingly, natural products inhibited IKK beta kinase as well as the 26S proteasome proteolytic activity. (C) 2009 Elsevier Inc. All rights reserved.

langue originale	English
Pages (de - à)	592-606
Nombre de pages	15
journal	BIOCHEM PHARMACOL
Numéro de publication	8
Les DOIs	https://doi.org/10.1016/j.bcp.2009.05.009
état	Published - 2009

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Ce résultat contribue à ou aux Objectifs de développement durable suivants

Good health and well being

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10.1016/j.bcp.2009.05.009

Contient cette citation

@article{4ce17b1312514134ac337bcc021fb59e,

title = "The inhibition of TNF-a induced NF-kB activation by marine natural products",

abstract = "The deregulated activation of NF-kappa B is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappa B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins. Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappa B-DNA binding as well as TNF-alpha-induced I kappa B alpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappa B activation induced by an overexpression of IKK beta. Interestingly, natural products inhibited IKK beta kinase as well as the 26S proteasome proteolytic activity. (C) 2009 Elsevier Inc. All rights reserved.",

keywords = " DRUG DEVELOPMENT, CHLOROCOCCUM SP, TRANSCRIPTION FACTOR, CANCER-THERAPY, GREEN-ALGA, TUMOR-NECROSIS-FACTOR, Pharmacology \& Pharmacy, FATTY-ACID, COMANTHUS-PARVICIRRUS, TARGETED MODULATORS, DNA-BINDING",

author = "Florence Folmer and Marcel Jaspars and Godofredo Solano and Silvia Cristofanon and Estelle Henry and Jioji Tabudravu and Kenny Black and David Green and Frithjof K{\"u}pper and William Aalbersberg and Klaus Feussner and Mario Dicato and Marc Diederich",

note = "Description 2* - few marine natural products inhibiting NF-kB are known, this study provides several new, interesting leads ",

year = "2009",

doi = "10.1016/j.bcp.2009.05.009",

language = "English",

pages = "592--606",

journal = "BIOCHEM PHARMACOL",

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T1 - The inhibition of TNF-a induced NF-kB activation by marine natural products

AU - Folmer, Florence

AU - Jaspars, Marcel

AU - Solano, Godofredo

AU - Cristofanon, Silvia

AU - Henry, Estelle

AU - Tabudravu, Jioji

AU - Black, Kenny

AU - Green, David

AU - Küpper, Frithjof

AU - Aalbersberg, William

AU - Feussner, Klaus

AU - Dicato, Mario

AU - Diederich, Marc

N1 - Description 2* - few marine natural products inhibiting NF-kB are known, this study provides several new, interesting leads

PY - 2009

Y1 - 2009

N2 - The deregulated activation of NF-kappa B is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappa B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins. Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappa B-DNA binding as well as TNF-alpha-induced I kappa B alpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappa B activation induced by an overexpression of IKK beta. Interestingly, natural products inhibited IKK beta kinase as well as the 26S proteasome proteolytic activity. (C) 2009 Elsevier Inc. All rights reserved.

AB - The deregulated activation of NF-kappa B is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappa B inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostellata, the crinoid Comanthus parvicirrus, the soft corals Sarcophyton sp. nov. and Sinularia sp., and the gorgonian Subergorgia sp. after an initial screening of 266 extracts from different marine origins. Results obtained show that selected purified compounds had a cytotoxic effect on the human leukaemia cell line K562, inhibited both TNF-alpha-induced NF-kappa B-DNA binding as well as TNF-alpha-induced I kappa B alpha degradation and nuclear translocation of p50/p65. Furthermore, we observed the inhibition of NF-kappa B activation induced by an overexpression of IKK beta. Interestingly, natural products inhibited IKK beta kinase as well as the 26S proteasome proteolytic activity. (C) 2009 Elsevier Inc. All rights reserved.

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KW - CHLOROCOCCUM SP

KW - TRANSCRIPTION FACTOR

KW - CANCER-THERAPY

KW - GREEN-ALGA

KW - TUMOR-NECROSIS-FACTOR

KW - Pharmacology & Pharmacy

KW - FATTY-ACID

KW - COMANTHUS-PARVICIRRUS

KW - TARGETED MODULATORS

KW - DNA-BINDING

U2 - 10.1016/j.bcp.2009.05.009

DO - 10.1016/j.bcp.2009.05.009

M3 - Article

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EP - 606

JO - BIOCHEM PHARMACOL

JF - BIOCHEM PHARMACOL

IS - 8

ER -

The inhibition of TNF-a induced NF-kB activation by marine natural products

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