New advances in blockade of the renin angiotensin system- The role of renin blockade

Sandra MacRury; L F Clark; G F Rushworth; Stephen J Leslie

doi:10.2174/157340210793611677

New advances in blockade of the renin angiotensin system- The role of renin blockade

Sandra MacRury
, L F Clark
, G F Rushworth
, Stephen J Leslie

Résultats de recherche: Article › Revue par des pairs

Résumé

Direct Renin Inhibitors (DRIs) are a new class of medication, and are the first which block the rate-limiting step of the renin-angiotensin-aldosterone-system (RAAS). Aliskiren, the first licensed orally active DRI, has been shown to be an effective antihypertensive agent. This review article outlines the pharmacological basis for DRI therapy, from discovery of the class to ongoing clinical trials and novel therapeutic applications of aliskiren.

langue originale	English
Pages (de - à)	222
Nombre de pages	231
journal	Current Hypertension Reviews
Volume	6
Numéro de publication	4
Les DOIs	https://doi.org/10.2174/157340210793611677
état	Published - 2014

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10.2174/157340210793611677

http://benthamscience.com/journal/abstracts.php?journalID=chr&articleID=72883

Contient cette citation

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title = "New advances in blockade of the renin angiotensin system- The role of renin blockade",

abstract = "Direct Renin Inhibitors (DRIs) are a new class of medication, and are the first which block the rate-limiting step of the renin-angiotensin-aldosterone-system (RAAS). Aliskiren, the first licensed orally active DRI, has been shown to be an effective antihypertensive agent. This review article outlines the pharmacological basis for DRI therapy, from discovery of the class to ongoing clinical trials and novel therapeutic applications of aliskiren. ",

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AU - Rushworth, G F

AU - Leslie, Stephen J

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Y1 - 2014

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AB - Direct Renin Inhibitors (DRIs) are a new class of medication, and are the first which block the rate-limiting step of the renin-angiotensin-aldosterone-system (RAAS). Aliskiren, the first licensed orally active DRI, has been shown to be an effective antihypertensive agent. This review article outlines the pharmacological basis for DRI therapy, from discovery of the class to ongoing clinical trials and novel therapeutic applications of aliskiren.

U2 - 10.2174/157340210793611677

DO - 10.2174/157340210793611677

M3 - Article

SN - 1875-6506

VL - 6

SP - 222

JO - Current Hypertension Reviews

JF - Current Hypertension Reviews

IS - 4

ER -

New advances in blockade of the renin angiotensin system- The role of renin blockade

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