Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

Chloe B. Rodgers; Natasa Broit; Peter A. Johansson; Antonia L. Pritchard

doi:10.1016/j.jid.2020.02.017

Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

Chloe B. Rodgers
, Natasa Broit
, Peter A. Johansson
, Antonia L. Pritchard

Résultats de recherche: Comment/debate › Revue par des pairs

2 Citations (Scopus)

Résumé

Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.

langue originale	English
Pages (de - à)	1501-1503
Nombre de pages	3
journal	Journal of Investigative Dermatology
Volume	140
Numéro de publication	8
Date de mise en ligne précoce	21 juil. 2020
Les DOIs	https://doi.org/10.1016/j.jid.2020.02.017
état	Published - 1 août 2020

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10.1016/j.jid.2020.02.017License: CC BY-NC-ND

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title = "Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors",

abstract = "Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.",

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AU - Rodgers, Chloe B.

AU - Broit, Natasa

AU - Johansson, Peter A.

AU - Pritchard, Antonia L.

PY - 2020/8/1

Y1 - 2020/8/1

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AB - Tumors are often polyclonal and are therefore heterogenous in their genomic and molecular profiles, which contributes to drug resistance and treatment failure. The methods used to detect these heterogenous differences in tumor samples are critical, but findings have been hindered by methodological inability to detect low-frequency subclones in bulk DNA. Chang et al. (2020) have addressed some of these methodological issues.

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C2 - 32709275

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JF - Journal of Investigative Dermatology

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ER -

Attack of the Subclones: Accurate Detection of Mutational Heterogeneity in Bulk DNA from Tumors

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