Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia

J Wei; C N Ramchand; G P Hemmings

Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia

J Wei
, C N Ramchand
, G P Hemmings

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37 Citations (Scopus)

Résumé

In the present study, five allelic fragments were typed by a polymerase chain reaction (PCR) process with a pair of primers specific for the tetranucleotide (TCAT) repeat sequence in the first intron of the human tyrosine hydroxylase (TH) gene and their sizes (bp) were 114 (A), 118 (B), 122 (C), 126 (D) and 130 (E), respectively. The AE genotypic frequency was found to be significantly higher in unrelated patients with schizophrenia than in unrelated control subjects (chi 2 = 4.18, p

langue originale	English
Pages (de - à)	83-8
Nombre de pages	6
journal	Psychiatric Genetics
Volume	5
Numéro de publication	2
état	Published - 1995

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@article{69469f136583489e91ba0dc98d9f8ea2,

title = "Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia",

abstract = "In the present study, five allelic fragments were typed by a polymerase chain reaction (PCR) process with a pair of primers specific for the tetranucleotide (TCAT) repeat sequence in the first intron of the human tyrosine hydroxylase (TH) gene and their sizes (bp) were 114 (A), 118 (B), 122 (C), 126 (D) and 130 (E), respectively. The AE genotypic frequency was found to be significantly higher in unrelated patients with schizophrenia than in unrelated control subjects (chi 2 = 4.18, p ",

keywords = "Adult, Alleles, Base Sequence, Catecholamines, Female, Great Britain, Humans, Introns, Male, Microsatellite Repeats, Middle Aged, Minisatellite Repeats, Molecular Sequence Data, Nerve Tissue Proteins, Norepinephrine, Polymerase Chain Reaction, Schizophrenia, Tyrosine 3-Monooxygenase",

author = "J Wei and Ramchand, \{C N\} and Hemmings, \{G P\}",

year = "1995",

language = "English",

volume = "5",

pages = "83--8",

journal = "Psychiatric Genetics",

issn = "0955-8829",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia

AU - Wei, J

AU - Ramchand, C N

AU - Hemmings, G P

PY - 1995

Y1 - 1995

N2 - In the present study, five allelic fragments were typed by a polymerase chain reaction (PCR) process with a pair of primers specific for the tetranucleotide (TCAT) repeat sequence in the first intron of the human tyrosine hydroxylase (TH) gene and their sizes (bp) were 114 (A), 118 (B), 122 (C), 126 (D) and 130 (E), respectively. The AE genotypic frequency was found to be significantly higher in unrelated patients with schizophrenia than in unrelated control subjects (chi 2 = 4.18, p

AB - In the present study, five allelic fragments were typed by a polymerase chain reaction (PCR) process with a pair of primers specific for the tetranucleotide (TCAT) repeat sequence in the first intron of the human tyrosine hydroxylase (TH) gene and their sizes (bp) were 114 (A), 118 (B), 122 (C), 126 (D) and 130 (E), respectively. The AE genotypic frequency was found to be significantly higher in unrelated patients with schizophrenia than in unrelated control subjects (chi 2 = 4.18, p

KW - Adult

KW - Alleles

KW - Base Sequence

KW - Catecholamines

KW - Female

KW - Great Britain

KW - Humans

KW - Introns

KW - Male

KW - Microsatellite Repeats

KW - Middle Aged

KW - Minisatellite Repeats

KW - Molecular Sequence Data

KW - Nerve Tissue Proteins

KW - Norepinephrine

KW - Polymerase Chain Reaction

KW - Schizophrenia

KW - Tyrosine 3-Monooxygenase

M3 - Article

C2 - 7551967

SN - 0955-8829

VL - 5

SP - 83

EP - 88

JO - Psychiatric Genetics

JF - Psychiatric Genetics

IS - 2

ER -

Association of polymorphic VNTR region in the first intron of the human TH gene with disturbances of the catecholamine pathway in schizophrenia

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