The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei; G P Hemmings

doi:10.1038/78044

The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei
, G P Hemmings

Producción científica: Article › revisión exhaustiva

156 Citas (Scopus)

Resumen

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

Idioma original	English
Páginas (desde-hasta)	376-7
Número de páginas	2
Publicación	Nature Genetics
Volumen	25
N.º	4
DOI	https://doi.org/10.1038/78044
Estado	Published - ago 2000

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title = "The NOTCH4 locus is associated with susceptibility to schizophrenia",

abstract = "Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.",

keywords = "Exons, Family Health, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Linkage Disequilibrium, Major Histocompatibility Complex, Male, Microsatellite Repeats, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Proto-Oncogene Proteins, Receptors, Cell Surface, Receptors, Notch, Schizophrenia, Trinucleotide Repeats",

author = "J Wei and Hemmings, \{G P\}",

year = "2000",

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doi = "10.1038/78044",

language = "English",

volume = "25",

pages = "376--7",

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AU - Hemmings, G P

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AB - Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

KW - Exons

KW - Family Health

KW - Female

KW - Genetic Predisposition to Disease

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Major Histocompatibility Complex

KW - Male

KW - Microsatellite Repeats

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Proto-Oncogene Proteins

KW - Receptors, Cell Surface

KW - Receptors, Notch

KW - Schizophrenia

KW - Trinucleotide Repeats

U2 - 10.1038/78044

DO - 10.1038/78044

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SN - 1061-4036

VL - 25

SP - 376

EP - 377

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

The NOTCH4 locus is associated with susceptibility to schizophrenia

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