NO and sGC-stimulating NO donors

Ian L Megson; Mark R Miller

doi:10.1007/978-3-540-68964-5_12

NO and sGC-stimulating NO donors

Ian L Megson
, Mark R Miller

Producción científica: Book/Film/Article review › revisión exhaustiva

12 Citas (Scopus)

Resumen

Our knowledge of nitric oxide (NO) as a crucial endogenous signalling molecule continues to expand. Many, but not all, of the actions of NO are mediated by activation of soluble guanylyl cyclase (sGC) in target tissues. The aim of this chapter is to encapsulate the functions of NO in mammalian biology, tied to the chemistry of this unusual signalling entity. The experimental usefulness and therapeutic potential of the most widely utilised NO donor drugs is reviewed, with special consideration given to the importance of choosing the correct NO donor for any given experiment, in vitro, in vivo or in clinical studies.

Idioma original	English
Páginas (desde-hasta)	247-76
Número de páginas	30
Publicación	Handbook of Experimental Pharmacology
N.º	191
DOI	https://doi.org/10.1007/978-3-540-68964-5_12
Estado	Published - 2009

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10.1007/978-3-540-68964-5_12

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abstract = "Our knowledge of nitric oxide (NO) as a crucial endogenous signalling molecule continues to expand. Many, but not all, of the actions of NO are mediated by activation of soluble guanylyl cyclase (sGC) in target tissues. The aim of this chapter is to encapsulate the functions of NO in mammalian biology, tied to the chemistry of this unusual signalling entity. The experimental usefulness and therapeutic potential of the most widely utilised NO donor drugs is reviewed, with special consideration given to the importance of choosing the correct NO donor for any given experiment, in vitro, in vivo or in clinical studies.",

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AU - Miller, Mark R

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AB - Our knowledge of nitric oxide (NO) as a crucial endogenous signalling molecule continues to expand. Many, but not all, of the actions of NO are mediated by activation of soluble guanylyl cyclase (sGC) in target tissues. The aim of this chapter is to encapsulate the functions of NO in mammalian biology, tied to the chemistry of this unusual signalling entity. The experimental usefulness and therapeutic potential of the most widely utilised NO donor drugs is reviewed, with special consideration given to the importance of choosing the correct NO donor for any given experiment, in vitro, in vivo or in clinical studies.

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DO - 10.1007/978-3-540-68964-5_12

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NO and sGC-stimulating NO donors

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