@article{2856787139f944948035b7b39e55c034,
title = "Butler enables rapid cloud-based analysis of thousands of human genomes",
abstract = "We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43\% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.",
author = "Sergei Yakneen and Waszak, \{Sebastian M.\} and Michael Gertz and Korbel, \{Jan O.\} and Brice Aminou and Javier Bartolome and Boroevich, \{Keith A.\} and Rich Boyce and Brooks, \{Angela N.\} and Alex Buchanan and Ivo Buchhalter and Butler, \{Adam P.\} and Byrne, \{Niall J.\} and Andy Cafferkey and Campbell, \{Peter J.\} and Zhaohong Chen and Sunghoon Cho and Wan Choi and Peter Clapham and Davis-Dusenbery, \{Brandi N.\} and \{De La Vega\}, \{Francisco M.\} and Jonas Demeulemeester and Dow, \{Michelle T.\} and Dursi, \{Lewis Jonathan\} and Juergen Eils and Roland Eils and Kyle Ellrott and Claudiu Farcas and Francesco Favero and Nodirjon Fayzullaev and Vincent Ferretti and Paul Flicek and Fonseca, \{Nuno A.\} and Gelpi, \{Josep L.L.\} and Gad Getz and Bob Gibson and Grossman, \{Robert L.\} and Olivier Harismendy and Heath, \{Allison P.\} and Heinold, \{Michael C.\} and Hess, \{Julian M.\} and Oliver Hofmann and Hong, \{Jongwhi H.\} and Hudson, \{Thomas J.\} and Barbara Hutter and Hutter, \{Carolyn M.\} and Daniel H{\"u}bschmann and Seiya Imoto and Sinisa Ivkovic and Pritchard, \{Antonia L.\}",
note = "{\textcopyright} 2020, The Author(s). Published by SpringerNature. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.",
year = "2020",
month = feb,
day = "5",
doi = "10.1038/s41587-019-0360-3",
language = "English",
volume = "38",
pages = "288--292",
journal = "Nature Biotechnology",
issn = "1087-0156",
publisher = "Nature Research",
number = "3",
}
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