Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

A G Japp; N L Cruden; G Barnes; N van Gemeren; J Mathews; J Adamson; N R Johnston; M A Denvir; I L Megson; A D Flapan; D E Newby

doi:10.1161/CIRCULATIONAHA.109.911339

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

A G Japp
, N L Cruden
, G Barnes
, N van Gemeren
, J Mathews
, J Adamson
, N R Johnston
, M A Denvir
, I L Megson
, A D Flapan
, D E Newby

Producción científica › revisión exhaustiva

306 Citas (Scopus)

Resumen

Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.

Idioma original	English
Páginas (desde-hasta)	1818-27
Número de páginas	10
Publicación	Circulation
Volumen	121
N.º	16
DOI	https://doi.org/10.1161/CIRCULATIONAHA.109.911339
Estado	Published - 2010

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10.1161/CIRCULATIONAHA.109.911339

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title = "Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure",

abstract = "Apelin, the endogenous ligand for the novel G protein-coupled receptor APJ, has major cardiovascular effects in preclinical models. The study objectives were to establish the effects of acute apelin administration on peripheral, cardiac, and systemic hemodynamic variables in healthy volunteers and patients with heart failure.",

author = "Japp, \{A G\} and Cruden, \{N L\} and G Barnes and \{van Gemeren\}, N and J Mathews and J Adamson and Johnston, \{N R\} and Denvir, \{M A\} and Megson, \{I L\} and Flapan, \{A D\} and Newby, \{D E\}",

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T2 - potential role in patients with chronic heart failure

AU - Japp, A G

AU - Cruden, N L

AU - Barnes, G

AU - van Gemeren, N

AU - Mathews, J

AU - Adamson, J

AU - Johnston, N R

AU - Denvir, M A

AU - Megson, I L

AU - Flapan, A D

AU - Newby, D E

PY - 2010

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U2 - 10.1161/CIRCULATIONAHA.109.911339

DO - 10.1161/CIRCULATIONAHA.109.911339

M3 - Article

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VL - 121

SP - 1818

EP - 1827

JO - Circulation

JF - Circulation

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ER -

Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure

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