A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J Webb; Ian L Megson; Nigel P Botting

doi:10.1039/c2cc38382a

A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang
, Agnieszka Kulczynska
, David J Webb
, Ian L Megson
, Nigel P Botting

Producción científica: Article › revisión exhaustiva

11 Citas (Scopus)

Resumen

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Idioma original	English
Páginas (desde-hasta)	1389-1391
Número de páginas	3
Publicación	Chemical Communications
Volumen	49
N.º	14
DOI	https://doi.org/10.1039/c2cc38382a
Estado	Published - 18 feb 2013

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abstract = "This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).",

keywords = "Acute Kidney Injury, Guanidines, Humans, Nitric Oxide, Prodrugs, Vasodilator Agents, gamma-Glutamyltransferase",

author = "Qingzhi Zhang and Agnieszka Kulczynska and Webb, \{David J\} and Megson, \{Ian L\} and Botting, \{Nigel P\}",

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AU - Kulczynska, Agnieszka

AU - Webb, David J

AU - Megson, Ian L

AU - Botting, Nigel P

N1 - cited By (since 1996)0

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AB - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of ¿-glutamyl transpeptidase (¿-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

KW - Acute Kidney Injury

KW - Guanidines

KW - Humans

KW - Nitric Oxide

KW - Prodrugs

KW - Vasodilator Agents

KW - gamma-Glutamyltransferase

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A new class of NO-donor pro-drugs triggered by ¿-glutamyl transpeptidase with potential for reno-selective vasodilatation

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