Vibrioferrin, an unusual marine siderophore: Iron binding, photochemistry, and biological implications

S A Amin, David Green, Frithjof Küpper, C J Carrano

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Vibrioferrin (VF) is a member of the carboxylate class of siderophores originally isolated from Vibrio parahaemolyticus, an enteropathogenic estuarine bacterium often associated with seafood-borne gastroenteritis. Recently we have also isolated this siderophore from several species of Marinobacter, which are closely associated or "symbiotic" with toxic, bloom-forming dinoflagellates such as Gymnodinium catenatum. We have measured the overall metal-ligand binding constant for iron-vibrioferrin (FeVF) as 10(24.02(5)) making vibrioferrin one of the weakest iron chelators of any known marine siderophore. FeVF is also shown to be considerably more sensitive to photolysis under relatively low illumination conditions than other photoactive siderophores leading primarily to a monodecarboxylated photoproduct that has no significant affinity for Fe(III). The consequences that these features have on bacterial-algal interactions with potential importance to understanding the origin and sustenance of harmful algal blooms are discussed.
Original languageEnglish
Pages (from-to)11451-11458
Number of pages8
JournalINORG CHEM
Volume48
DOIs
Publication statusPublished - 2009

Keywords

  • Chemistry, Inorganic & Nuclear
  • BACTERIUM
  • IRON(III)
  • DINOFLAGELLATE GYMNODINIUM-CATENATUM
  • COORDINATION CHEMISTRY
  • AMPHIPHILIC SIDEROPHORES
  • TRANSPORT
  • MEMBRANE AFFINITY
  • COMPLEXING LIGANDS
  • EQUILIBRIUM-CONSTANTS
  • PARAHAEMOLYTICUS

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