Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea

Zhong Jiang; Kenneth G. Boyd; Andrew Mearns-spragg; David R. Adams; Phillip C. Wright; J. Grant Burgess

doi:10.1080/10575630008043781

Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea

Zhong Jiang, Kenneth G. Boyd, Andrew Mearns-spragg, David R. Adams, Phillip C. Wright, J. Grant Burgess

Environmental Research Institute

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Two diketopiperazines, cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline), and 2,4-dibromo-6-chlorophenol were isolated from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea. Cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline) stimulated antibiotic production in this strain. 2,4-Dibromo-6-chlorophenol showed antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and the cystic fibrosis associated pathogen Burkholderia cepacia.

Original language	English
Pages (from-to)	435-440
Number of pages	6
Journal	Natural Product Letters
Volume	14
Issue number	6
DOIs	https://doi.org/10.1080/10575630008043781
Publication status	Published - 2000

Keywords

2, 4-dibromo-6-chlorophenol
Antibiotic
Cyclo-(L-phenylalanyl-4R-hydroxy-L-proline)
Cyclo-(L-prolyl-L-glycine)
Pseudoalteromonas luteoviolacea

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea",

abstract = "Two diketopiperazines, cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline), and 2,4-dibromo-6-chlorophenol were isolated from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea. Cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline) stimulated antibiotic production in this strain. 2,4-Dibromo-6-chlorophenol showed antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and the cystic fibrosis associated pathogen Burkholderia cepacia.",

keywords = "2, 4-dibromo-6-chlorophenol, Antibiotic, Cyclo-(L-phenylalanyl-4R-hydroxy-L-proline), Cyclo-(L-prolyl-L-glycine), Pseudoalteromonas luteoviolacea",

author = "Zhong Jiang and Boyd, {Kenneth G.} and Andrew Mearns-spragg and Adams, {David R.} and Wright, {Phillip C.} and Burgess, {J. Grant}",

note = "Funding Information: The authors thank Scottish Hospital Endowments Research Trust (RG9/99) and Natural and Environmental Research Council (GST/02/1633) for financial support. A. M-S. thanks Heriot-Watt University for the award of a University Scholarship. We also thank Prof. Sebastian Amyes (Department of Medical Microbiology, Edinburgh University) for providing MRSA 955 1, B. cepacia 5415, and E. coli EMG 9 for screening. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2000",

doi = "10.1080/10575630008043781",

language = "English",

volume = "14",

pages = "435--440",

journal = "Natural Product Letters",

issn = "1057-5634",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea

AU - Jiang, Zhong

AU - Boyd, Kenneth G.

AU - Mearns-spragg, Andrew

AU - Adams, David R.

AU - Wright, Phillip C.

AU - Burgess, J. Grant

N1 - Funding Information: The authors thank Scottish Hospital Endowments Research Trust (RG9/99) and Natural and Environmental Research Council (GST/02/1633) for financial support. A. M-S. thanks Heriot-Watt University for the award of a University Scholarship. We also thank Prof. Sebastian Amyes (Department of Medical Microbiology, Edinburgh University) for providing MRSA 955 1, B. cepacia 5415, and E. coli EMG 9 for screening. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2000

Y1 - 2000

N2 - Two diketopiperazines, cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline), and 2,4-dibromo-6-chlorophenol were isolated from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea. Cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline) stimulated antibiotic production in this strain. 2,4-Dibromo-6-chlorophenol showed antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and the cystic fibrosis associated pathogen Burkholderia cepacia.

AB - Two diketopiperazines, cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline), and 2,4-dibromo-6-chlorophenol were isolated from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea. Cyclo-(L-prolyl-L-glycine) and cyclo-(L-phenylalanyl-4R-hydroxy-L-proline) stimulated antibiotic production in this strain. 2,4-Dibromo-6-chlorophenol showed antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and the cystic fibrosis associated pathogen Burkholderia cepacia.

KW - 2, 4-dibromo-6-chlorophenol

KW - Antibiotic

KW - Cyclo-(L-phenylalanyl-4R-hydroxy-L-proline)

KW - Cyclo-(L-prolyl-L-glycine)

KW - Pseudoalteromonas luteoviolacea

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DO - 10.1080/10575630008043781

M3 - Article

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SN - 1057-5634

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JO - Natural Product Letters

JF - Natural Product Letters

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ER -

Two diketopiperazines and one halogenated phenol from cultures of the marine bacterium, Pseudoalteromonas luteoviolacea

Abstract

Keywords

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