Tuning the Nitric Oxide Release from CPO-27 MOFs

Damiano Cattaneo; Stewart J Warrender; Morven J. Duncan; Christopher J Kelsall; Mary K Doherty; Phillip Whitfield; Ian Megson; Russell Morris

doi:10.1039/C5RA24023A

Tuning the Nitric Oxide Release from CPO-27 MOFs

Damiano Cattaneo, Stewart J Warrender, Morven J. Duncan, Christopher J Kelsall, Mary K Doherty, Phillip Whitfield, Ian Megson, Russell Morris

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Abstract

Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications

Original language	English
Pages (from-to)	14059-14067
Number of pages	8
Journal	RSC Adv.
Volume	17
Issue number	6
Early online date	26 Jan 2016
DOIs	https://doi.org/10.1039/C5RA24023A
Publication status	Published - 26 Jan 2016

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10.1039/C5RA24023ALicence: CC BY

Cattaneo_et_al_Tuning_the_Nitric_Oxide_Release_from_CPO_27_MOFS
© 2017 The Authors. Published by the Royal Society of Chemistry
Submitted manuscript, 2.54 MBLicence: CC BY
Tuning the nitric oxide release from CPO-27 MOFs
© 2017 The Authors. Published by the Royal Society of Chemistry
Final published version, 2.62 MBLicence: CC BY

http://pubs.rsc.org/en/Content/ArticleLanding/2016/RA/C5RA24023ALicence: CC BY

Ian Megson
- ian.megsonuhi.acuk
- Division of Biomedical Sciences - Head of Health Research
- Research Office
Person: Academic - Research and Teaching or Research only

Cite this

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title = "Tuning the Nitric Oxide Release from CPO-27 MOFs",

abstract = "Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications",

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AU - Warrender, Stewart J

AU - Duncan, Morven J.

AU - Kelsall, Christopher J

AU - Doherty, Mary K

AU - Whitfield, Phillip

AU - Megson, Ian

AU - Morris, Russell

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AB - Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications

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JF - RSC Adv.

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Tuning the Nitric Oxide Release from CPO-27 MOFs

Abstract

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