Tuning the Nitric Oxide Release from CPO-27 MOFs

Damiano Cattaneo, Stewart J Warrender, Morven J. Duncan, Christopher J Kelsall, Mary K Doherty, Phillip Whitfield, Ian Megson, Russell Morris

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Abstract

Nitric Oxide (NO) storage and release measurements have been recorded for Ni-doped CPO-27 (Mg) and CPO-27 (Zn), and the biological effect of the released NO was assessed in porcine coronary artery relaxation tests. The results indicate that the doping strategy leads to increased levels of NO storage and delivery compared to the parent materials and that NO dosage and biological response can be tuned via this approach to suit the requirements of particular applications
Original languageEnglish
Pages (from-to)14059-14067
Number of pages8
JournalRSC Adv.
Volume17
Issue number6
Early online date26 Jan 2016
DOIs
Publication statusPublished - 26 Jan 2016

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Cattaneo, D., Warrender, S. J., Duncan, M. J., Kelsall, C. J., Doherty, M. K., Whitfield, P., ... Morris, R. (2016). Tuning the Nitric Oxide Release from CPO-27 MOFs. RSC Adv., 17(6), 14059-14067. https://doi.org/10.1039/C5RA24023A