Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

M J Finnen; A Hennessy; S McLean; Y Bisset; R Mitchell; I L Megson; R Weller

doi:10.1111/j.1365-2133.2007.08063.x

Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

M J Finnen, A Hennessy, S McLean, Y Bisset, R Mitchell, I L Megson, R Weller

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17 Citations (Scopus)

Abstract

Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).

Original language	English
Pages (from-to)	494-500
Number of pages	7
Journal	The British Journal of Dermatology
Volume	157
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2133.2007.08063.x
Publication status	Published - 2007

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title = "Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate",

abstract = "Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).",

author = "Finnen, {M J} and A Hennessy and S McLean and Y Bisset and R Mitchell and Megson, {I L} and R Weller",

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AU - Finnen, M J

AU - Hennessy, A

AU - McLean, S

AU - Bisset, Y

AU - Mitchell, R

AU - Megson, I L

AU - Weller, R

PY - 2007

Y1 - 2007

N2 - Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).

AB - Topical treatment of nail diseases is hampered by the nail plate barrier, consisting of dense cross-linked keratin fibres held together by cysteine-rich proteins and disulphide bonds, which prevents penetration of antifungal agents to the focus of fungal infection. Acidified nitrite is an effective treatment for tinea pedis. It releases nitric oxide (NO) and other NO-related species. NO can react with thiol (-SH) groups to form nitrosothiols (-SNO).

U2 - 10.1111/j.1365-2133.2007.08063.x

DO - 10.1111/j.1365-2133.2007.08063.x

M3 - Article

C2 - 17627796

SN - 0007-0963

VL - 157

SP - 494

EP - 500

JO - The British Journal of Dermatology

JF - The British Journal of Dermatology

IS - 3

ER -

Topical application of acidified nitrite to the nail renders it antifungal and causes nitrosation of cysteine groups in the nail plate

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