To clot or not to clot? That is a free radical question

Daniel R Crabtree, David Muggeridge, Stephen J Leslie, Ian L Megson, James N Cobley

Research output: Contribution to journalEditorialpeer-review

1 Citation (Scopus)
32 Downloads (Pure)


Unravelling the biological roles of reactive oxygen species (ROS) is challenging (Murphy et al. 2011). There are three key challenges: (1) the global term ‘ROS’ subsumes chemically diverse free radical and non‐radical species making it difficult to attribute a particular effect to a particular species; (2) nutritional antioxidants often fail to react appreciably with key ROS (e.g. superoxide anion, O2.−) at the desired time and place; and (3) measuring ROS is a perennial difficulty because their short half‐lives (usually in the order of milliseconds) can preclude direct detection (Murphy et al. 2011). It is unsurprising, therefore, that few suspected biological roles of ROS have been confirmed in humans, especially in an exercise context that presents its own unique experimental challenges. For example, debate still exists as to whether ROS regulate key adaptive responses to exercise (Margaritelis et al. 2016).
Original languageEnglish
Pages (from-to)4805-4806
Number of pages2
JournalJournal of Physiology
Issue number20
Early online date21 Aug 2018
Publication statusPublished - 9 Sept 2018


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