Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes

Kyle R Gibson; Tim J Winterburn; Fiona Barrett; Sushma Sharma; Sandra M MacRury; Ian L Megson

doi:10.1186/1475-2840-10-43

Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes

Kyle R Gibson
, Tim J Winterburn
, Fiona Barrett
, Sushma Sharma
, Sandra M MacRury
, Ian L Megson

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Platelet hyperaggregability is a pro-thrombotic feature of type-2 diabetes, associated with low levels of the antioxidant glutathione (GSH). Clinical delivery of N-acetylcysteine (NAC), a biosynthetic precursor of GSH, may help redress a GSH shortfall in platelets, thereby reducing thrombotic risk in type-2 diabetes patients. We investigated the effect of NAC in vitro, at concentrations attainable with tolerable oral dosing, on platelet GSH concentrations and aggregation propensity in blood from patients with type-2 diabetes.

Original language	English
Pages (from-to)	43
Journal	Cardiovascular Diabetology
Volume	10
DOIs	https://doi.org/10.1186/1475-2840-10-43
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1186/1475-2840-10-43

Cite this

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abstract = "Platelet hyperaggregability is a pro-thrombotic feature of type-2 diabetes, associated with low levels of the antioxidant glutathione (GSH). Clinical delivery of N-acetylcysteine (NAC), a biosynthetic precursor of GSH, may help redress a GSH shortfall in platelets, thereby reducing thrombotic risk in type-2 diabetes patients. We investigated the effect of NAC in vitro, at concentrations attainable with tolerable oral dosing, on platelet GSH concentrations and aggregation propensity in blood from patients with type-2 diabetes.",

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AU - MacRury, Sandra M

AU - Megson, Ian L

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AB - Platelet hyperaggregability is a pro-thrombotic feature of type-2 diabetes, associated with low levels of the antioxidant glutathione (GSH). Clinical delivery of N-acetylcysteine (NAC), a biosynthetic precursor of GSH, may help redress a GSH shortfall in platelets, thereby reducing thrombotic risk in type-2 diabetes patients. We investigated the effect of NAC in vitro, at concentrations attainable with tolerable oral dosing, on platelet GSH concentrations and aggregation propensity in blood from patients with type-2 diabetes.

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Therapeutic potential of N-acetylcysteine as an antiplatelet agent in patients with type-2 diabetes

Abstract

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