The TGM2 gene is associated with schizophrenia in a British population

Matilda Bradford, Matthew H Law, Andrew D Stewart, Duncan J Shaw, Ian L Megson, Jun Wei

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Several lines of evidence have suggested an interesting link between gluten ingestion and schizophrenia. Increased levels of gliadin antibodies have been observed in patients with schizophrenia. Tissue transglutaminase (transglutaminase 2, TGM2) is involved in the production of gliadin antibodies. To investigate genetic association of the TGM2 gene with schizophrenia, we detected eight single nucleotide polymorphisms (SNPs) present in the gene among 131 family trios composed of fathers, mothers and affected offspring with schizophrenia. Data analysis with the UNPHASED program showed allelic association for rs2076380 (chi(2) = 5.51, P = 0.019), rs7270785 (chi(2) = 8.13, P = 0.004), rs4811528 (chi(2) = 6.13, P = 0.013) and rs6023526 (chi(2) = 6.13, P = 0.013). The global P-value was 0.029 for 10,000 permutations with the TDT analysis. The strongest association was observed for the rs7270785-rs4811528 haplotypes (chi(2) = 16.18, df = 3, P = 0.001), and the global P-value was 0.008 for 10,000 permutations with the 2-SNP haplotype analysis. The 8-SNP haplotype analysis also revealed a strong haplotypic association (chi(2) = 44.82, df = 18, P = 0.0004) and the 1-df test showed that the A-T-A-A-T-G-A-G haplotype was excessively transmitted (chi(2) = 16.98, corrected P = 0.0007). The present results suggest that the TGM2 gene may be involved in the development of schizophrenia.
Original languageEnglish
Pages (from-to)335-40
Number of pages6
JournalAmerican Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Issue number3
Publication statusPublished - 2009


Dive into the research topics of 'The TGM2 gene is associated with schizophrenia in a British population'. Together they form a unique fingerprint.

Cite this