The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei, G P Hemmings

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.
Original languageEnglish
Pages (from-to)376-7
Number of pages2
JournalNature Genetics
Volume25
Issue number4
DOIs
Publication statusPublished - Aug 2000

Keywords

  • Exons
  • Family Health
  • Female
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Major Histocompatibility Complex
  • Male
  • Microsatellite Repeats
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins
  • Receptors, Cell Surface
  • Receptors, Notch
  • Schizophrenia
  • Trinucleotide Repeats

Fingerprint Dive into the research topics of 'The NOTCH4 locus is associated with susceptibility to schizophrenia'. Together they form a unique fingerprint.

  • Cite this