The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei; G P Hemmings

doi:10.1038/78044

The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei, G P Hemmings

Research output: Contribution to journal › Article › peer-review

149 Citations (Scopus)

Abstract

Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

Original language	English
Pages (from-to)	376-7
Number of pages	2
Journal	Nature Genetics
Volume	25
Issue number	4
DOIs	https://doi.org/10.1038/78044
Publication status	Published - Aug 2000

Keywords

Exons
Family Health
Female
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Major Histocompatibility Complex
Male
Microsatellite Repeats
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Proto-Oncogene Proteins
Receptors, Cell Surface
Receptors, Notch
Schizophrenia
Trinucleotide Repeats

Access to Document

10.1038/78044

Cite this

@article{3d2875fc89914f1bb9bf47c3d74da537,

title = "The NOTCH4 locus is associated with susceptibility to schizophrenia",

abstract = "Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.",

keywords = "Exons, Family Health, Female, Genetic Predisposition to Disease, Haplotypes, Humans, Linkage Disequilibrium, Major Histocompatibility Complex, Male, Microsatellite Repeats, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Proto-Oncogene Proteins, Receptors, Cell Surface, Receptors, Notch, Schizophrenia, Trinucleotide Repeats",

author = "J Wei and Hemmings, {G P}",

year = "2000",

month = aug,

doi = "10.1038/78044",

language = "English",

volume = "25",

pages = "376--7",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - The NOTCH4 locus is associated with susceptibility to schizophrenia

AU - Wei, J

AU - Hemmings, G P

PY - 2000/8

Y1 - 2000/8

N2 - Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

AB - Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.

KW - Exons

KW - Family Health

KW - Female

KW - Genetic Predisposition to Disease

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Major Histocompatibility Complex

KW - Male

KW - Microsatellite Repeats

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Proto-Oncogene Proteins

KW - Receptors, Cell Surface

KW - Receptors, Notch

KW - Schizophrenia

KW - Trinucleotide Repeats

U2 - 10.1038/78044

DO - 10.1038/78044

M3 - Article

C2 - 10932176

SN - 1061-4036

VL - 25

SP - 376

EP - 377

JO - Nature Genetics

JF - Nature Genetics

IS - 4

ER -

The NOTCH4 locus is associated with susceptibility to schizophrenia

Abstract

Keywords

Access to Document

Fingerprint

Cite this