The NOTCH4 locus is associated with susceptibility to schizophrenia

J Wei, G P Hemmings

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)


Linkage disequilibrium mapping of the MHC region in 80 British parent-offspring trios showed that NOTCH4 was highly associated with schizophrenia. The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia.
Original languageEnglish
Pages (from-to)376-7
Number of pages2
JournalNature Genetics
Issue number4
Publication statusPublished - Aug 2000


  • Exons
  • Family Health
  • Female
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Major Histocompatibility Complex
  • Male
  • Microsatellite Repeats
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins
  • Receptors, Cell Surface
  • Receptors, Notch
  • Schizophrenia
  • Trinucleotide Repeats


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