Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population

Jun Wei

doi:10.1016/j.psychres.2016.03.057

Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population

Jun Wei

Division of Biomedical Sciences

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

A genome-wide association study of Han Chinese samples identified three
single-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to be
associated with schizophrenia. However, the replication of the TSPAN18
association was inconsistent across studies. To explore the possible reason for
poor replication, we conducted a case-control study to validate the TSPAN18
finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thought
disorder. Our result suggested that the TSPAN18 gene may be involved in the
development of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia.

Original language	English
Pages (from-to)	263-266
Number of pages	4
Journal	Psychiatry Research
Volume	241
DOIs	https://doi.org/10.1016/j.psychres.2016.03.057
Publication status	Published - 11 May 2016

Keywords

Tetraspanin 18
Schizophrenia
Heterogeneity

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Wei, J. (2016). Study of the tetraspanin 18 association with schizophrenia in a Han Chinese population. Psychiatry Research , 241, 263-266. https://doi.org/10.1016/j.psychres.2016.03.057

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abstract = "A genome-wide association study of Han Chinese samples identified threesingle-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to beassociated with schizophrenia. However, the replication of the TSPAN18association was inconsistent across studies. To explore the possible reason forpoor replication, we conducted a case-control study to validate the TSPAN18finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thoughtdisorder. Our result suggested that the TSPAN18 gene may be involved in thedevelopment of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia.",

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AB - A genome-wide association study of Han Chinese samples identified threesingle-nucleotide polymorphisms in the tetraspanin 18 (TSPAN18) gene to beassociated with schizophrenia. However, the replication of the TSPAN18association was inconsistent across studies. To explore the possible reason forpoor replication, we conducted a case-control study to validate the TSPAN18finding in an independent Chinese sample. The frequency of rs11038167 minor allele (A) was significantly higher only in female patients with thoughtdisorder. Our result suggested that the TSPAN18 gene may be involved in thedevelopment of psychotic symptoms and contribute to clinical heterogeneity of schizophrenia.

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