Recurrent inactivating RASA2 mutations in melanoma

Rand Arafeh; Nouar Qutob; Rafi Emmanuel; Alona Keren-Paz; Jason Madore; Abdel Elkahloun; James S. Wilmott; Jared J. Gartner; Antonella Di Pizio; Sabina Winograd-Katz; Sivasish Sindiri; Ron Rotkopf; Ken Dutton-Regester; Peter A. Johansson; Antonia L. Pritchard; Nicola Waddell; Victoria K. Hill; Jimmy C. Lin; Yael Hevroni; Steven A. Rosenberg; Javed Khan; Shifra Ben-Dor; Masha Y. Niv; Igor Ulitsky; Graham J. Mann; Richard A. Scolyer; Nicholas K. Hayward; Yardena Samuels

doi:10.1038/ng.3427

Recurrent inactivating RASA2 mutations in melanoma

Rand Arafeh, Nouar Qutob, Rafi Emmanuel, Alona Keren-Paz, Jason Madore, Abdel Elkahloun, James S. Wilmott, Jared J. Gartner, Antonella Di Pizio, Sabina Winograd-Katz, Sivasish Sindiri, Ron Rotkopf, Ken Dutton-Regester, Peter A. Johansson, Antonia L. Pritchard, Nicola Waddell, Victoria K. Hill, Jimmy C. Lin, Yael Hevroni, Steven A. RosenbergJaved Khan, Shifra Ben-Dor, Masha Y. Niv, Igor Ulitsky, Graham J. Mann, Richard A. Scolyer, Nicholas K. Hayward, Yardena Samuels

Division of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.

Original language	English
Pages (from-to)	1408-1410
Number of pages	3
Journal	Nature Genetics
Volume	47
Issue number	12
Early online date	26 Oct 2015
DOIs	https://doi.org/10.1038/ng.3427
Publication status	Published - Dec 2015

Keywords

3ref2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Antonia Pritchard
- antonia.pritcharduhi.acuk
- Division of Biomedical Sciences - Reader in Genetics and Immunology
- Melanoma Research Group
Person: Academic - Research and Teaching or Research only

Cite this

Arafeh, R., Qutob, N., Emmanuel, R., Keren-Paz, A., Madore, J., Elkahloun, A., Wilmott, J. S., Gartner, J. J., Di Pizio, A., Winograd-Katz, S., Sindiri, S., Rotkopf, R., Dutton-Regester, K., Johansson, P. A., Pritchard, A. L., Waddell, N., Hill, V. K., Lin, J. C., Hevroni, Y., ... Samuels, Y. (2015). Recurrent inactivating RASA2 mutations in melanoma. Nature Genetics, 47(12), 1408-1410. https://doi.org/10.1038/ng.3427

@article{25f0ad9889374656a857bac84bef5983,

title = "Recurrent inactivating RASA2 mutations in melanoma",

abstract = "Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.",

keywords = "3ref2021",

author = "Rand Arafeh and Nouar Qutob and Rafi Emmanuel and Alona Keren-Paz and Jason Madore and Abdel Elkahloun and Wilmott, {James S.} and Gartner, {Jared J.} and {Di Pizio}, Antonella and Sabina Winograd-Katz and Sivasish Sindiri and Ron Rotkopf and Ken Dutton-Regester and Johansson, {Peter A.} and Pritchard, {Antonia L.} and Nicola Waddell and Hill, {Victoria K.} and Lin, {Jimmy C.} and Yael Hevroni and Rosenberg, {Steven A.} and Javed Khan and Shifra Ben-Dor and Niv, {Masha Y.} and Igor Ulitsky and Mann, {Graham J.} and Scolyer, {Richard A.} and Hayward, {Nicholas K.} and Yardena Samuels",

year = "2015",

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doi = "10.1038/ng.3427",

language = "English",

volume = "47",

pages = "1408--1410",

journal = "Nature Genetics",

issn = "1061-4036",

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Arafeh, R, Qutob, N, Emmanuel, R, Keren-Paz, A, Madore, J, Elkahloun, A, Wilmott, JS, Gartner, JJ, Di Pizio, A, Winograd-Katz, S, Sindiri, S, Rotkopf, R, Dutton-Regester, K, Johansson, PA, Pritchard, AL, Waddell, N, Hill, VK, Lin, JC, Hevroni, Y, Rosenberg, SA, Khan, J, Ben-Dor, S, Niv, MY, Ulitsky, I, Mann, GJ, Scolyer, RA, Hayward, NK & Samuels, Y 2015, 'Recurrent inactivating RASA2 mutations in melanoma', Nature Genetics, vol. 47, no. 12, pp. 1408-1410. https://doi.org/10.1038/ng.3427

TY - JOUR

T1 - Recurrent inactivating RASA2 mutations in melanoma

AU - Arafeh, Rand

AU - Qutob, Nouar

AU - Emmanuel, Rafi

AU - Keren-Paz, Alona

AU - Madore, Jason

AU - Elkahloun, Abdel

AU - Wilmott, James S.

AU - Gartner, Jared J.

AU - Di Pizio, Antonella

AU - Winograd-Katz, Sabina

AU - Sindiri, Sivasish

AU - Rotkopf, Ron

AU - Dutton-Regester, Ken

AU - Johansson, Peter A.

AU - Pritchard, Antonia L.

AU - Waddell, Nicola

AU - Hill, Victoria K.

AU - Lin, Jimmy C.

AU - Hevroni, Yael

AU - Rosenberg, Steven A.

AU - Khan, Javed

AU - Ben-Dor, Shifra

AU - Niv, Masha Y.

AU - Ulitsky, Igor

AU - Mann, Graham J.

AU - Scolyer, Richard A.

AU - Hayward, Nicholas K.

AU - Samuels, Yardena

PY - 2015/12

Y1 - 2015/12

N2 - Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.

AB - Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.

KW - 3ref2021

U2 - 10.1038/ng.3427

DO - 10.1038/ng.3427

M3 - Article

SN - 1061-4036

VL - 47

SP - 1408

EP - 1410

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

Recurrent inactivating RASA2 mutations in melanoma

Abstract

Keywords

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