Protein turnover on the scale of the proteome

Mary K Doherty, Robert J Beynon

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Protein turnover is a neglected dimension in postgenomic studies, defining the dynamics of changes in protein expression and forging a link between transcriptome, proteome and metabolome. Recent advances in postgenomic technologies have led to the development of new proteomic techniques to measure protein turnover on a proteome-wide scale. These methods are driven by stable isotope metabolic labeling of cells in culture or in intact animals. This review considers the merits and difficulties of different methods that allow access to proteome dynamics.
Original languageEnglish
Pages (from-to)97-110
Number of pages14
JournalExpert Review of Proteomics
Issue number1
Publication statusPublished - Feb 2006


  • Animals
  • Humans
  • Isotope Labeling
  • Proteins
  • Proteome
  • Proteomics


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