Protein interactome of muscle invasive bladder cancer

Akshay Bhat, Andreas Heinzel, Bernd Mayer, Paul Perco, Irmgard Mühlberger, Holger Husi, Axel S. Merseburger, Jerome Zoidakis, Antonia Vlahou, Joost P. Schanstra, Harald Mischak, Vera Jankowski

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Muscle invasive bladder carcinoma is a complex, multifactorial disease caused by disruptions and alterations of several molecular pathways that result in heterogeneous phenotypes and variable disease outcome. Combining this disparate knowledge may offer insights for deciphering relevant molecular processes regarding targeted therapeutic approaches guided by molecular signatures allowing improved phenotype profiling. The aim of the study is to characterize muscle invasive bladder carcinoma on a molecular level by incorporating scientific literature screening and signatures from omics profiling. Public domain omics signatures together with molecular features associated with muscle invasive bladder cancer were derived from literature mining to provide 286 unique protein-coding genes. These were integrated in a protein-interaction network to obtain a molecular functional map of the phenotype. This feature map educated on three novel disease-associated pathways with plausible involvement in bladder cancer, namely Regulation of actin cytoskeleton, Neurotrophin signalling pathway and Endocytosis. Systematic integration approaches allow to study the molecular context of individual features reported as associated with a clinical phenotype and could potentially help to improve the molecular mechanistic description of the disorder.
Original languageEnglish
JournalPLoS ONE
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Jan 2015

Fingerprint Dive into the research topics of 'Protein interactome of muscle invasive bladder cancer'. Together they form a unique fingerprint.

Cite this