Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Wan-Seob Cho, Rodger Duffin, Sarah E M Howie, Chris J Scotton, William A H Wallace, William Macnee, Mark Bradley, Ian L Megson, Ken Donaldson

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the pathological changes induced by ZnONP and their possible mechanism of action.
Original languageEnglish
Pages (from-to)27
JournalParticle and Fibre Toxicology
Volume8
DOIs
Publication statusPublished - 2011

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    Cho, W-S., Duffin, R., Howie, S. E. M., Scotton, C. J., Wallace, W. A. H., Macnee, W., Bradley, M., Megson, I. L., & Donaldson, K. (2011). Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Particle and Fibre Toxicology, 8, 27. https://doi.org/10.1186/1743-8977-8-27