Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Wan-Seob Cho; Rodger Duffin; Sarah E M Howie; Chris J Scotton; William A H Wallace; William Macnee; Mark Bradley; Ian L Megson; Ken Donaldson

doi:10.1186/1743-8977-8-27

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Wan-Seob Cho, Rodger Duffin, Sarah E M Howie, Chris J Scotton, William A H Wallace, William Macnee, Mark Bradley, Ian L Megson, Ken Donaldson

Research output: Contribution to journal › Article › peer-review

358 Citations (Scopus)

Abstract

Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the pathological changes induced by ZnONP and their possible mechanism of action.

Original language	English
Pages (from-to)	27
Journal	Particle and Fibre Toxicology
Volume	8
DOIs	https://doi.org/10.1186/1743-8977-8-27
Publication status	Published - 2011

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10.1186/1743-8977-8-27

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title = "Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes",

abstract = "Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the pathological changes induced by ZnONP and their possible mechanism of action.",

author = "Wan-Seob Cho and Rodger Duffin and Howie, {Sarah E M} and Scotton, {Chris J} and Wallace, {William A H} and William Macnee and Mark Bradley and Megson, {Ian L} and Ken Donaldson",

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AU - Cho, Wan-Seob

AU - Duffin, Rodger

AU - Howie, Sarah E M

AU - Scotton, Chris J

AU - Wallace, William A H

AU - Macnee, William

AU - Bradley, Mark

AU - Megson, Ian L

AU - Donaldson, Ken

PY - 2011

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N2 - Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the pathological changes induced by ZnONP and their possible mechanism of action.

AB - Large production volumes of zinc oxide nanoparticles (ZnONP) might be anticipated to pose risks, of accidental inhalation in occupational and even in consumer settings. Herein, we further investigated the pathological changes induced by ZnONP and their possible mechanism of action.

U2 - 10.1186/1743-8977-8-27

DO - 10.1186/1743-8977-8-27

M3 - Article

C2 - 21896169

SN - 1743-8977

VL - 8

SP - 27

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

ER -

Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Abstract

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