Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Wan-Seob Cho, Rodger Duffin, Mark Bradley, Ian L Megson, William Macnee, Jong Kwon Lee, Jayoung Jeong, Ken Donaldson

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs makes in vivo toxicity tests undesirable on both ethical and financial grounds, creating an urgent need for development of in vitro cell-based assays that accurately predict in vivo toxicity and facilitate safe nanotechnology.
Original languageEnglish
Pages (from-to)55
JournalParticle and Fibre Toxicology
Volume10
Issue number1
DOIs
Publication statusPublished - 25 Oct 2013

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