Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Wan-Seob Cho; Rodger Duffin; Mark Bradley; Ian L Megson; William Macnee; Jong Kwon Lee; Jayoung Jeong; Ken Donaldson

doi:10.1186/1743-8977-10-55

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Wan-Seob Cho, Rodger Duffin, Mark Bradley, Ian L Megson, William Macnee, Jong Kwon Lee, Jayoung Jeong, Ken Donaldson

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108 Citations (Scopus)

Abstract

Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs makes in vivo toxicity tests undesirable on both ethical and financial grounds, creating an urgent need for development of in vitro cell-based assays that accurately predict in vivo toxicity and facilitate safe nanotechnology.

Original language	English
Pages (from-to)	55
Journal	Particle and Fibre Toxicology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/1743-8977-10-55
Publication status	Published - 25 Oct 2013

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abstract = "Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs makes in vivo toxicity tests undesirable on both ethical and financial grounds, creating an urgent need for development of in vitro cell-based assays that accurately predict in vivo toxicity and facilitate safe nanotechnology.",

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AU - Cho, Wan-Seob

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AU - Megson, Ian L

AU - Macnee, William

AU - Lee, Jong Kwon

AU - Jeong, Jayoung

AU - Donaldson, Ken

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N2 - Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs makes in vivo toxicity tests undesirable on both ethical and financial grounds, creating an urgent need for development of in vitro cell-based assays that accurately predict in vivo toxicity and facilitate safe nanotechnology.

AB - Hazard identification for risk assessment of nanoparticles (NPs) is mainly composed of in vitro cell-based assays and in vivo animal experimentation. The rapidly increasing number and functionalizations of NPs makes in vivo toxicity tests undesirable on both ethical and financial grounds, creating an urgent need for development of in vitro cell-based assays that accurately predict in vivo toxicity and facilitate safe nanotechnology.

U2 - 10.1186/1743-8977-10-55

DO - 10.1186/1743-8977-10-55

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JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

IS - 1

ER -

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Abstract

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