Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals

J Wei; C N Ramchand; G P Hemmings

Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals

J Wei, C N Ramchand, G P Hemmings

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Six allelic fragments were typed by a PCR-based process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat at the human dopamine beta-hydroxylase (DBH) locus in 125 unrelated healthy individuals. Their frequencies among these individuals were 0.012 (A1), 0.08 (A2), 0.344 (A3), 0.548 (A4), 0.004 (A5) and 0.012 (A6); the two major alleles, A3 and A4, made up nearly 90% of the alleles. These individuals were divided into four groups according to the genotype they possessed, i.e. A3/A3, A4/A4, A3/A4 and others (mixed group). Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among these four genetic groups (H = 32.7, P

Original language	English
Pages (from-to)	52-5
Number of pages	4
Journal	Human Molecular Genetics
Volume	99
Issue number	1
Publication status	Published - Jan 1997

Keywords

Alleles
Base Sequence
DNA Primers
Dinucleotide Repeats
Dopamine beta-Hydroxylase
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Genetic
Reference Values

Cite this

@article{bdf9584a3f7843a3b95b1e6357a62aad,

title = "Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals",

abstract = "Six allelic fragments were typed by a PCR-based process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat at the human dopamine beta-hydroxylase (DBH) locus in 125 unrelated healthy individuals. Their frequencies among these individuals were 0.012 (A1), 0.08 (A2), 0.344 (A3), 0.548 (A4), 0.004 (A5) and 0.012 (A6); the two major alleles, A3 and A4, made up nearly 90% of the alleles. These individuals were divided into four groups according to the genotype they possessed, i.e. A3/A3, A4/A4, A3/A4 and others (mixed group). Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among these four genetic groups (H = 32.7, P ",

keywords = "Alleles, Base Sequence, DNA Primers, Dinucleotide Repeats, Dopamine beta-Hydroxylase, Female, Gene Frequency, Genotype, Humans, Male, Middle Aged, Molecular Sequence Data, Polymerase Chain Reaction, Polymorphism, Genetic, Reference Values",

author = "J Wei and Ramchand, {C N} and Hemmings, {G P}",

year = "1997",

month = jan,

language = "English",

volume = "99",

pages = "52--5",

journal = "Human Molecular Genetics",

issn = "0340-6717",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals

AU - Wei, J

AU - Ramchand, C N

AU - Hemmings, G P

PY - 1997/1

Y1 - 1997/1

N2 - Six allelic fragments were typed by a PCR-based process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat at the human dopamine beta-hydroxylase (DBH) locus in 125 unrelated healthy individuals. Their frequencies among these individuals were 0.012 (A1), 0.08 (A2), 0.344 (A3), 0.548 (A4), 0.004 (A5) and 0.012 (A6); the two major alleles, A3 and A4, made up nearly 90% of the alleles. These individuals were divided into four groups according to the genotype they possessed, i.e. A3/A3, A4/A4, A3/A4 and others (mixed group). Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among these four genetic groups (H = 32.7, P

AB - Six allelic fragments were typed by a PCR-based process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat at the human dopamine beta-hydroxylase (DBH) locus in 125 unrelated healthy individuals. Their frequencies among these individuals were 0.012 (A1), 0.08 (A2), 0.344 (A3), 0.548 (A4), 0.004 (A5) and 0.012 (A6); the two major alleles, A3 and A4, made up nearly 90% of the alleles. These individuals were divided into four groups according to the genotype they possessed, i.e. A3/A3, A4/A4, A3/A4 and others (mixed group). Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among these four genetic groups (H = 32.7, P

KW - Alleles

KW - Base Sequence

KW - DNA Primers

KW - Dinucleotide Repeats

KW - Dopamine beta-Hydroxylase

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Male

KW - Middle Aged

KW - Molecular Sequence Data

KW - Polymerase Chain Reaction

KW - Polymorphism, Genetic

KW - Reference Values

M3 - Article

C2 - 9003494

SN - 0340-6717

VL - 99

SP - 52

EP - 55

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 1

ER -

Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals

Abstract

Keywords

Fingerprint

Cite this