Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals

J Wei, C N Ramchand, G P Hemmings

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Six allelic fragments were typed by a PCR-based process with a pair of primers specific for a sequence containing the polymorphic (GT)n repeat at the human dopamine beta-hydroxylase (DBH) locus in 125 unrelated healthy individuals. Their frequencies among these individuals were 0.012 (A1), 0.08 (A2), 0.344 (A3), 0.548 (A4), 0.004 (A5) and 0.012 (A6); the two major alleles, A3 and A4, made up nearly 90% of the alleles. These individuals were divided into four groups according to the genotype they possessed, i.e. A3/A3, A4/A4, A3/A4 and others (mixed group). Kruskal-Wallis analysis revealed a significant difference in serum DBH activity among these four genetic groups (H = 32.7, P
Original languageEnglish
Pages (from-to)52-5
Number of pages4
JournalHuman Molecular Genetics
Volume99
Issue number1
Publication statusPublished - Jan 1997

Keywords

  • Alleles
  • Base Sequence
  • DNA Primers
  • Dinucleotide Repeats
  • Dopamine beta-Hydroxylase
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Reference Values

Fingerprint Dive into the research topics of 'Possible control of dopamine beta-hydroxylase via a codominant mechanism associated with the polymorphic (GT)n repeat at its gene locus in healthy individuals'. Together they form a unique fingerprint.

  • Cite this