Photochemistry of trans-Cr(cyclam)(ONO)2+, a nitric oxide precursor

Alexis D Ostrowski, Ryan O Absalonson, Malcolm A De Leo, Guang Wu, James G Pavlovich, Janet Adamson, Bilal Azhar, Alexei V Iretskii, Ian L Megson, Peter C Ford

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Abstract

Experimental and density functional theory (DFT) studies are described that are focused on outlining the reactivity of the known photochemical nitric oxide precursor trans-Cr(cyclam)(ONO)(2)(+) ("CrONO", cyclam = 1,4,8,11-tetrazacycltetradecane). Studies in both aerated and deaerated aqueous media are described as are the roles of both the oxidant O(2) and a reductant such as glutathione in trapping the apparent Cr(IV) photoreaction intermediate trans-Cr(cyclam)(O)(ONO)(+). Also reported and characterized structurally is the Cr(V) product of long-term photolysis in the absence of reducing agents, the trans-dioxo species [trans-Cr(cyclam)(O)(2)](ClO(4)). Photosensitization experiments indicate that at least a significant fraction of the reaction occurs from the lowest energy doublet excited state(s). Lastly, cell culture experiments demonstrate that CrONO has little or no acute toxicity either before or after photolysis.
Original languageEnglish
Pages (from-to)4453-62
Number of pages10
JournalInorganic Chemistry
Volume50
Issue number10
DOIs
Publication statusPublished - 2011

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    Ostrowski, A. D., Absalonson, R. O., De Leo, M. A., Wu, G., Pavlovich, J. G., Adamson, J., Azhar, B., Iretskii, A. V., Megson, I. L., & Ford, P. C. (2011). Photochemistry of trans-Cr(cyclam)(ONO)2+, a nitric oxide precursor. Inorganic Chemistry, 50(10), 4453-62. https://doi.org/10.1021/ic200094x