Oxidative stress and inflammation in the development of cardiovascular disease and contrast induced nephropathy

Karla Cerventes-Gracia, Khuram Raja, Daniel Llanas-Cornejo, James Cobley, Ian Megson, Richard Chahwan, Holger Husi

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Abstract

Utilization of contrast media to visualize vasculature structures in the setting of cardiovascular disorders (CVD)
can lead to acute kidney injury, referred to as contrast-induced nephropathy (CIN). CIN can potentiate mortality
and hospitalization in aged individuals, patients with CVD, nephropathy, enhancing kidney damage, and cardiac
events. Preventing CIN by identifying risk factors is important. The underlying mechanisms of CIN pathology are
unclear, but the key factors include direct cytotoxicity, oxidative stress, vascular and endothelial dysfunction and
inflammatory processes. Reactive Oxygen Species and inflammatory mediators have been proposed as key factors
influencing the development of CIN and CVD, and the elucidation of the interplay between the mechanisms
evoked by them may provide a better understanding of the signaling processes happening in these conditions,
thereby potentially enabling early identification, prevention and characterization of novel drug targets.
Original languageEnglish
Number of pages19
JournalVessel Plus
Volume4
Issue number27
DOIs
Publication statusPublished - 1 Sep 2020

Keywords

  • Contrast induced nephropathy
  • cardiovascular disorders
  • oxidative stress
  • inflammation
  • reactive oxygen species

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