Abstract
It has been suggested that gluten consumption is linked to schizophrenia, with this link strengthened through the presence of circulating anti-native gliadin antibodies (AGAs). The human leukocyte antigen (HLA) system is crucial for antigen presentation and antibody secretion but no study has examined the relationship between HLA-II variants and circulating antibodies against gliadin peptides. In this study, HLA-II variants were genotyped in patients with schizophrenia and the relationship between these variants and plasma AGA levels was examined. Although there was no association found, HLA-AGA associations could potentially serve as a marker of gluten sensitivity in patients with schizophrenia.
Original language | English |
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Article number | 0165-1781 |
Pages (from-to) | 325-327 |
Number of pages | 3 |
Journal | Psychiatry Research |
Volume | 271 |
Early online date | 1 Dec 2018 |
DOIs | |
Publication status | Published - 1 Jan 2019 |
Keywords
- Gluten antibodies; HLA; schizophrenia