No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population

Y-Q Yu; R Tao; J Wei; Q Xu; S-Z Liu; G-Z Ju; J-P Shi; X Zhang; L Xie; Y Shen

doi:10.1016/j.plefa.2004.09.001

No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population

Y-Q Yu, R Tao, J Wei, Q Xu, S-Z Liu, G-Z Ju, J-P Shi, X Zhang, L Xie, Y Shen

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Abstract

The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.

Original language	English
Pages (from-to)	405-8
Number of pages	4
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	71
Issue number	6
DOIs	https://doi.org/10.1016/j.plefa.2004.09.001
Publication status	Published - Dec 2004

Keywords

Asian Continental Ancestry Group
China
Cyclooxygenase 2
Female
Gene Frequency
Haplotypes
Humans
Linkage Disequilibrium
Male
Membrane Proteins
Phospholipases A
Polymorphism, Single Nucleotide
Prostaglandin-Endoperoxide Synthases
Schizophrenia

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title = "No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population",

abstract = "The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.",

keywords = "Asian Continental Ancestry Group, China, Cyclooxygenase 2, Female, Gene Frequency, Haplotypes, Humans, Linkage Disequilibrium, Male, Membrane Proteins, Phospholipases A, Polymorphism, Single Nucleotide, Prostaglandin-Endoperoxide Synthases, Schizophrenia",

author = "Y-Q Yu and R Tao and J Wei and Q Xu and S-Z Liu and G-Z Ju and J-P Shi and X Zhang and L Xie and Y Shen",

year = "2004",

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doi = "10.1016/j.plefa.2004.09.001",

language = "English",

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T1 - No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population

AU - Yu, Y-Q

AU - Tao, R

AU - Wei, J

AU - Xu, Q

AU - Liu, S-Z

AU - Ju, G-Z

AU - Shi, J-P

AU - Zhang, X

AU - Xie, L

AU - Shen, Y

PY - 2004/12

Y1 - 2004/12

N2 - The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.

AB - The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.

KW - Asian Continental Ancestry Group

KW - China

KW - Cyclooxygenase 2

KW - Female

KW - Gene Frequency

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Membrane Proteins

KW - Phospholipases A

KW - Polymorphism, Single Nucleotide

KW - Prostaglandin-Endoperoxide Synthases

KW - Schizophrenia

U2 - 10.1016/j.plefa.2004.09.001

DO - 10.1016/j.plefa.2004.09.001

M3 - Article

C2 - 15519500

SN - 0952-3278

VL - 71

SP - 405

EP - 408

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 6

ER -

No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population

Abstract

Keywords

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