No association between the PTGS2/PLA2G4A locus and schizophrenia in a Chinese population

Y-Q Yu, R Tao, J Wei, Q Xu, S-Z Liu, G-Z Ju, J-P Shi, X Zhang, L Xie, Y Shen

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The present study was undertaken to replicate an association between the PTGS2/PLA2G4A locus and schizophrenia among a Chinese population. We recruited 168 Chinese parent-offspring trios of Han descent, consisting of fathers, mothers and affected offspring with schizophrenia. Of 3 informative SNPs genotyped, no one showed allelic association with schizophrenia; the haplotype analysis also failed to capture a haplotypic association with the illness. Because the frequencies of alleles and genotypes of SNPs analyzed differ in the Chinese population as compared with a British population that initially showed the genetic association between the PTGS2/PLA2G4A locus and schizophrenia, the ethnic background may be a major reason for poor replication of the initial finding.
Original languageEnglish
Pages (from-to)405-8
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume71
Issue number6
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Asian Continental Ancestry Group
  • China
  • Cyclooxygenase 2
  • Female
  • Gene Frequency
  • Haplotypes
  • Humans
  • Linkage Disequilibrium
  • Male
  • Membrane Proteins
  • Phospholipases A
  • Polymorphism, Single Nucleotide
  • Prostaglandin-Endoperoxide Synthases
  • Schizophrenia

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