NO and sGC-stimulating NO donors

Ian L Megson; Mark R Miller

doi:10.1007/978-3-540-68964-5_12

NO and sGC-stimulating NO donors

Ian L Megson, Mark R Miller

Research output: Contribution to journal › Book/Film/Article review › peer-review

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Abstract

Our knowledge of nitric oxide (NO) as a crucial endogenous signalling molecule continues to expand. Many, but not all, of the actions of NO are mediated by activation of soluble guanylyl cyclase (sGC) in target tissues. The aim of this chapter is to encapsulate the functions of NO in mammalian biology, tied to the chemistry of this unusual signalling entity. The experimental usefulness and therapeutic potential of the most widely utilised NO donor drugs is reviewed, with special consideration given to the importance of choosing the correct NO donor for any given experiment, in vitro, in vivo or in clinical studies.

Original language	English
Pages (from-to)	247-76
Number of pages	30
Journal	Handbook of Experimental Pharmacology
Issue number	191
DOIs	https://doi.org/10.1007/978-3-540-68964-5_12
Publication status	Published - 2009

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abstract = "Our knowledge of nitric oxide (NO) as a crucial endogenous signalling molecule continues to expand. Many, but not all, of the actions of NO are mediated by activation of soluble guanylyl cyclase (sGC) in target tissues. The aim of this chapter is to encapsulate the functions of NO in mammalian biology, tied to the chemistry of this unusual signalling entity. The experimental usefulness and therapeutic potential of the most widely utilised NO donor drugs is reviewed, with special consideration given to the importance of choosing the correct NO donor for any given experiment, in vitro, in vivo or in clinical studies.",

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AB - Our knowledge of nitric oxide (NO) as a crucial endogenous signalling molecule continues to expand. Many, but not all, of the actions of NO are mediated by activation of soluble guanylyl cyclase (sGC) in target tissues. The aim of this chapter is to encapsulate the functions of NO in mammalian biology, tied to the chemistry of this unusual signalling entity. The experimental usefulness and therapeutic potential of the most widely utilised NO donor drugs is reviewed, with special consideration given to the importance of choosing the correct NO donor for any given experiment, in vitro, in vivo or in clinical studies.

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DO - 10.1007/978-3-540-68964-5_12

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JO - Handbook of Experimental Pharmacology

JF - Handbook of Experimental Pharmacology

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ER -

NO and sGC-stimulating NO donors

Abstract

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