Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis

E L Taylor, I L Megson, C Haslett, A G Rossi

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Apoptosis of inflammatory cells is a critical event in the resolution of inflammation, as failure to undergo this form of cell death leads to increased tissue damage and exacerbation of the inflammatory response. Many factors are able to influence the rate of apoptosis in neutrophils, eosinophils, monocytes and macrophages. Among these is the signalling molecule nitric oxide (NO), which possesses both anti- and proapoptotic properties, depending on the concentration and flux of NO, and also the source from which NO is derived. This review summarises the differential effects of NO on inflammatory cell apoptosis and outlines potential mechanisms that have been proposed to explain such actions.
Original languageEnglish
Pages (from-to)418-30
Number of pages13
JournalCell Death and Differentiation
Volume10
Issue number4
DOIs
Publication statusPublished - 2003

Fingerprint Dive into the research topics of 'Nitric oxide: a key regulator of myeloid inflammatory cell apoptosis'. Together they form a unique fingerprint.

  • Cite this