New advances in blockade of the renin angiotensin system- The role of renin blockade

Sandra MacRury; L F Clark; G F Rushworth; Stephen J Leslie

doi:10.2174/157340210793611677

New advances in blockade of the renin angiotensin system- The role of renin blockade

Sandra MacRury, L F Clark, G F Rushworth, Stephen J Leslie

Research output: Contribution to journal › Article › peer-review

Abstract

Direct Renin Inhibitors (DRIs) are a new class of medication, and are the first which block the rate-limiting step of the renin-angiotensin-aldosterone-system (RAAS). Aliskiren, the first licensed orally active DRI, has been shown to be an effective antihypertensive agent. This review article outlines the pharmacological basis for DRI therapy, from discovery of the class to ongoing clinical trials and novel therapeutic applications of aliskiren.

Original language	English
Pages (from-to)	222
Number of pages	231
Journal	Current Hypertension Reviews
Volume	6
Issue number	4
DOIs	https://doi.org/10.2174/157340210793611677
Publication status	Published - 2014

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10.2174/157340210793611677

http://benthamscience.com/journal/abstracts.php?journalID=chr&articleID=72883

Sandra MacRury
- EX67SMuhi.acuk
- Research Office - Professor Emerita
Person: Academic Related

Cite this

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title = "New advances in blockade of the renin angiotensin system- The role of renin blockade",

abstract = "Direct Renin Inhibitors (DRIs) are a new class of medication, and are the first which block the rate-limiting step of the renin-angiotensin-aldosterone-system (RAAS). Aliskiren, the first licensed orally active DRI, has been shown to be an effective antihypertensive agent. This review article outlines the pharmacological basis for DRI therapy, from discovery of the class to ongoing clinical trials and novel therapeutic applications of aliskiren. ",

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New advances in blockade of the renin angiotensin system- The role of renin blockade

Abstract

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